Morphometric measurements of systemic atherosclerosis and visceral fat: Evidence from an autopsy study
| Autor: | Renata Eloah de Lucena Ferretti-Rebustini, Fernanda Marinho Campos, Aline Nishizawa, Renata Elaine Paraizo Leite, Wilson Jacob-Filho, Claudia K. Suemoto, Carlos Augusto Pasqualucci, José Marcelo Farfel, Márcio Sommer Bittencourt, Daniela Souza Farias-Itao, Karen Cristina Souza da Silva, Lea T. Grinberg |
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| Přispěvatelé: | Sun, Qinghua |
| Rok vydání: | 2017 |
| Předmět: |
Male
Aging Cerebral arteries lcsh:Medicine Adipose tissue Autopsy 030204 cardiovascular system & hematology Cardiovascular Pathology and Laboratory Medicine Vascular Medicine Biochemistry Fats 0302 clinical medicine 80 and over Medicine and Health Sciences lcsh:Science Coronary Arteries Aorta Stenosis Aged 80 and over Aortic atherosclerosis Multidisciplinary Confounding Arteries Middle Aged Lipids Heart Disease Carotid Arteries medicine.anatomical_structure Cardiology Female Anatomy Research Article Adult medicine.medical_specialty General Science & Technology Surgical and Invasive Medical Procedures and over Intra-Abdominal Fat 03 medical and health sciences Signs and Symptoms Diagnostic Medicine medicine.artery Internal medicine medicine Humans cardiovascular diseases Heart Disease - Coronary Heart Disease Aged business.industry lcsh:R Biology and Life Sciences Cerebral Arteries Atherosclerosis medicine.disease Coronary arteries Cardiovascular Anatomy Blood Vessels lcsh:Q business 030217 neurology & neurosurgery |
| Zdroj: | PLoS ONE, Vol 12, Iss 10, p e0186630 (2017) PLoS ONE PloS one, vol 12, iss 10 |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0186630 |
| Popis: | Author(s): Nishizawa, Aline; Suemoto, Claudia K; Farias-Itao, Daniela S; Campos, Fernanda M; Silva, Karen CS; Bittencourt, Marcio S; Grinberg, Lea T; Leite, Renata EP; Ferretti-Rebustini, Renata EL; Farfel, Jose M; Jacob-Filho, Wilson; Pasqualucci, Carlos A | Abstract: BACKGROUND:Morphometric measurements of systemic atherosclerosis and direct quantification of visceral fat are only possible using materials from autopsy studies. However, the few autopsy studies that have investigated the association of visceral fat with atherosclerosis had small sample sizes and focused on coronary arteries of young or middle-aged White subjects. We aimed to investigate the association of pericardial fat (PF) and abdominal visceral fat (AVF) with atherosclerosis in the aorta, coronary, carotid, and cerebral arteries in a large autopsy study. MATERIALS AND METHODS:We evaluated deceased subjects aged 30 years or above. We dissected and weighted the PF and the AVF and evaluated the atherosclerotic burden in the aorta, as well as the carotid, coronary, and cerebral arteries using morphometric measurements. We also investigated the interaction of PF and AVF with age regarding the atherosclerotic burden. RESULTS:The mean age of the 240 included subjects was 64.8±15.3 years, and 63% was male. Greater PF was associated with a higher degree of aortic atherosclerosis after adjusting for confounding variables (coefficient = 4.39, 95% CI = 0.83; 7.94, p = 0.02). Greater AVF was associated with a higher coronary stenosis index (coefficient = 1.49, 95% CI = 0.15; 2.83, p = 0.03) and a greater number of coronary plaques (coefficient = 0.71, 95% CI = 0.24; 1.19, p = 0.003). We did not find an association of PF or AVF with carotid or cerebral atherosclerotic burden. We found a significant interaction of AVF (coefficient = -0.08; 95% CI = -0.14; -0.02, p = 0.009) and PF (coefficient = -0.87, 95% CI = -1.70; -0.04, p = 0.04) with age regarding carotid artery atherosclerotic burden. CONCLUSIONS:Greater AVF was associated with greater atherosclerotic burden and extent in coronary arteries, while greater PF correlated with a higher degree of atherosclerosis in the aorta. |
| Databáze: | OpenAIRE |
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