Role of deficient type III interferon-lambda production in asthma exacerbations
| Autor: | Anita Lewis-Antes, Louise Slater, Michael R. Edwards, Donna E. Davies, Nathan W. Bartlett, Luminita A. Stanciu, Simon D. Message, Tatiana Kebadze, Alberto Papi, Hayley L. Parker, Vasile Laza-Stanca, Patrick Mallia, Sergei V. Kotenko, Peter A. B. Wark, Sebastian L. Johnston, Onn Min Kon, Marco Contoli, Stephen T. Holgate |
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| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
Lipopolysaccharides
Exacerbation Lipopolysaccharide Rhinovirus viruses medicine.disease_cause General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound stomatognathic system medicine Humans Virus load Cells Cultured Asthma Asthma exacerbations Picornaviridae Infections business.industry Extramural Interleukins General Medicine respiratory system Interferon λ medicine.disease respiratory tract diseases chemistry Immunology Cytokines Interferons business Bronchoalveolar Lavage Fluid |
| Popis: | Rhinoviruses are the major cause of asthma exacerbations, and asthmatics have increased susceptibility to rhinovirus and risk of invasive bacterial infections. Here we show deficient induction of interferon-lambdas by rhinovirus in asthmatic primary bronchial epithelial cells and alveolar macrophages, which was highly correlated with severity of rhinovirus-induced asthma exacerbation and virus load in experimentally infected human volunteers. Induction by lipopolysaccharide in asthmatic macrophages was also deficient and correlated with exacerbation severity. These results identify previously unknown mechanisms of susceptibility to infection in asthma and suggest new approaches to prevention and/or treatment of asthma exacerbations. |
| Databáze: | OpenAIRE |
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