Alcohol-assisted debridement in PRK with intraoperative mitomycin C
| Autor: | Maryam Haghnegahdar, Nariman Nassiri, Saman Nassiri, Kourosh Sheibani, Nekoo Panahi, Nader Nassiri, Sare Safi, Shiva Mehravaran |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Alkylating Agents Stromal cell genetic structures medicine.medical_treatment Corneal Stroma Mitomycin Cell Count Corneal Keratocytes Photorefractive Keratectomy law.invention Intraoperative Period Young Adult Stroma Confocal microscopy law Ophthalmology Cell density Myopia Medicine Humans Prospective Studies Dioptre Debridement Microscopy Confocal Ethanol business.industry Mitomycin C Endothelium Corneal Middle Aged eye diseases Photorefractive keratectomy Solvents Female Lasers Excimer sense organs business Optometry |
| Zdroj: | Optometry and vision science : official publication of the American Academy of Optometry. 91(9) |
| ISSN: | 1538-9235 |
| Popis: | PURPOSE To compare corneal stromal and endothelial cells after photorefractive keratectomy with intraoperative mitomycin C in alcohol-assisted versus mechanical epithelial debridement using confocal microscopy. METHODS This prospective randomized comparative study was performed on 88 eyes (44 patients) with myopia up to -6.00 diopters. The right eye of each patient was randomly assigned to either mechanical or alcohol-assisted groups, and the left eye was assigned to the alternate group. Confocal microscopy was performed preoperatively and at 3 months postoperatively. The main outcome measures were epithelial thickness; number of keratocytes in the anterior, mid-, and posterior stroma; and characteristics of the central corneal endothelial cells in terms of density, mean cell area, and polymegathism and hexagonality. RESULTS Three months after surgery, no statistically significant difference was noted between the study groups in terms of epithelial thickness. We also found no statistically significant difference in central corneal endothelial cells regarding cell density, mean cell area, hexagonality, or polymegathism. Compared with baseline values, the density of mid- and posterior stromal keratocytes showed no significant change in either group, whereas it decreased significantly in the anterior stroma in both groups 3 months after surgery. CONCLUSIONS We found that the adverse effects of photorefractive keratectomy with mitomycin C on central corneal endothelial cells were comparable between the mechanical and alcohol-assisted epithelial debridement groups and the significant decrease in postoperative keratocyte density in anterior stroma was comparable between the two groups. The choice of their application could be left to the discretion of the ophthalmologist. |
| Databáze: | OpenAIRE |
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