Effect of transfer of human ApoA1 gene on development of dyslipoproteinemias in rats: Age peculiarities

Autor:	I.E. Kostetsky, Novikova Sn, Sabko Ve, V.A. Kordjum, R.I Potapenko, V. N. Shulzhenko, Mozzhukhina Tg, Vladimir V. Frolkis, A.L. Shkapenko, L.N Bogatskaya, G. I. Paramonova
Rok vydání:	1990
Předmět:	Aging medicine.medical_specialty Health (social science) Lipid composition Genetic transfer Biology Endocrinology Internal medicine APOA1 Gene medicine lipids (amino acids peptides and proteins) Geriatrics and Gerontology Gerontology Gene
Zdroj:	Archives of gerontology and geriatrics. 13(3)
ISSN:	0167-4943
Popis:	Transfer of human ApoA1 gene within the molecular construction which provides its expression, to the liver of the adult and aged rats resulted in the appearance of human protein in their blood, and was accompanied by changes in the content of high-density lipoproteins and of their subclasses HDL 3 and HDL 2 , as well as by the shifts in their protein and lipid composition. Synthesis of human ApoA1 was more marked in the organism of adult rats, and gene-regulatory shifts in aged rats.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abd3cf476e2de25fc3a6468757bb60ed https://pubmed.ncbi.nlm.nih.gov/15374415 Zobrazit plný text záznamu