A novel redox cycle diverts cells from oncogene-induced senescence into cancer
| Autor: | Mate Maus, Manuel Serrano |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Senescence
Oncogens Antioxidant medicine.medical_treatment Redox cycle Biology Metabolisme cel·lular law.invention Malignant transformation 03 medical and health sciences 0302 clinical medicine law Neoplasms medicine Humans Molecular Biology Cellular Senescence 030304 developmental biology 0303 health sciences Cell metabolism Cancer Cell Biology Oncogenes medicine.disease digestive system diseases Cancer research Oncogene-induced senescence Suppressor Tumor Suppressor Protein p53 Oxidation-Reduction 030217 neurology & neurosurgery |
| Zdroj: | Molecular Cell Dipòsit Digital de la UB Universidad de Barcelona |
| Popis: | Igelmann et al. report a novel metabolic cycle, which they name HTC, that converts NADH into the key antioxidant factor NADPH. The HTC is repressed by the tumor suppressors p53 and RB, and this determines whether oncogene-expressing cells undergo senescence (HTCoff) or malignant transformation (HTCon). Copyright © 2021 Elsevier Inc. All rights reserved. |
| Databáze: | OpenAIRE |
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