Acipimox enhances spontaneous growth hormone secretion in obese women
| Autor: | Inge H. A. P. van Ierssel, A. Edo Meinders, Marijke Frölich, Ferdinand Roelfsema, Hanno Pijl, Petra Kok, Peter J. Voshol, Simon W. Kok, Madelon M. Buijs |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
medicine.medical_specialty Acipimox Physiology Entropy Fatty Acids Nonesterified Biology Endocrine secretion Pathogenesis Physiology (medical) Internal medicine medicine Humans Lipolysis Obesity Insulin-Like Growth Factor I Hypolipidemic Agents chemistry.chemical_classification Human Growth Hormone Fatty acid medicine.disease Growth hormone secretion Endocrinology Adipose Tissue chemistry Pyrazines Body Composition Female Body mass index Half-Life medicine.drug |
| Zdroj: | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 286:R693-R698 |
| ISSN: | 1522-1490 0363-6119 |
| DOI: | 10.1152/ajpregu.00595.2003 |
| Popis: | We hypothesized that a high circulating free fatty acid (FFA) concentration is involved in the pathogenesis of hyposomatotropism associated with obesity. To evaluate this hypothesis, 10 healthy premenopausal women (body mass index 33.8 ± 1.0 kg/m2) were studied in the follicular phase of their menstrual cycle at two occasions with a time interval of at least 8 wk, where body weight remained stable. Subjects were randomly assigned to treatment with either acipimox (an inhibitor of lipolysis, 250 mg orally 4 times daily) or placebo in a double-blind crossover design, starting 1 day before admission until the end of the blood sampling period. Blood samples were taken during 24 h with a sampling interval of 10 min for assessment of growth hormone (GH) concentrations, and GH secretion was estimated by deconvolution analysis. Identical methodology was used to study GH secretion in a historical control group of age-matched normal weight women. GH secretion was clearly blunted in obese women (total daily release 66 ± 10 vs. lean controls: 201 ± 23 mU·lVd-1·24 h-1, P = 0.005, where lVd is liter of distribution volume). Acipimox considerably enhanced total (113 ± 50 vs. 66 ± 10 mU·lVd-1·24 h-1, P = 0.02) and pulsatile GH secretion (109 ± 49 vs. 62 ± 30 mU·lVd-1·24 h-1, P = 0.02), but GH output remained lower compared with lean controls. Further analysis did not show any relationship between the effects of acipimox on GH secretion and regional body fat distribution. In conclusion, acipimox unleashes spontaneous GH secretion in obese women. It specifically enhances GH secretory burst mass. This might mean that lowering of systemic FFA concentrations by acipimox modulates neuroendocrine mechanisms that orchestrate the activity of the somatotropic ensemble. |
| Databáze: | OpenAIRE |
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