CDH1 Testing: Can it Predict the Prophylactic or Therapeutic Nature of Total Gastrectomy in Hereditary Diffuse Gastric Cancer?
| Autor: | Dimitrios H Roukos, Dimosthenis Ziogas |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
Oncology
medicine.medical_specialty medicine.medical_treatment Population Breast cancer Surgical oncology Antigens CD Gastrectomy Stomach Neoplasms Internal medicine medicine Humans Genetic Testing Family history education Genetic testing education.field_of_study medicine.diagnostic_test business.industry General surgery Cancer medicine.disease Cadherins Prognosis Mutation Surgery Hereditary diffuse gastric cancer business |
| Zdroj: | Annals of Surgical Oncology. 16(10):2678-2681 |
| ISSN: | 1068-9265 |
| DOI: | 10.1245/s10434-009-0598-y |
| Popis: | Gastric cancer has a poor prognosis. Primary prevention is a major goal to reduce incidence and mortality, but it is still an illusion. There is an exception: the rare hereditary diffuse gastric cancer (HDGC). This syndrome can be both accurately predicted and successfully prevented. How? If we could identify high-risk individuals in the general population and subsequently tailor an effective preventive intervention, then we could protect them by saving their lives. This achievement is now realistic, although it concerns a small only fraction of cases. Genetic testing in individuals with a family history of diffuse gastric cancer allows for identification of family members with inherited mutations at CDH1 gene. These mutation carriers have a very high risk of developing diffuse gastric cancer 1 and women have an additional lobular breast cancer risk. 2 This HDGC syndrome is characterized by early onset and requires primary prevention at a young age. 1,2 |
| Databáze: | OpenAIRE |
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