Comparison of clinicopathological features and outcomes in patients with primary leiomyosarcoma of bone and soft tissue
| Autor: | Alan T. Blank, Charles A Gusho, Steven Gitelis |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Leiomyosarcoma Oncology Cancer Research medicine.medical_specialty Adolescent medicine.medical_treatment Bone Neoplasms Soft Tissue Neoplasms Malignancy Cohort Studies Young Adult 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans In patient Child Aged Aged 80 and over Chemotherapy Proportional hazards model business.industry Hazard ratio Infant Newborn Infant Soft tissue General Medicine Middle Aged Prognosis medicine.disease Combined Modality Therapy Confidence interval Survival Rate Amputation Child Preschool 030220 oncology & carcinogenesis Primary Leiomyosarcoma Clinicopathological features Female 030211 gastroenterology & hepatology Surgery Radiology business Follow-Up Studies |
| Zdroj: | Journal of Surgical Oncology. 123:1274-1283 |
| ISSN: | 1096-9098 0022-4790 |
| Popis: | e23526 Background: Leiomyosarcoma is a rare malignancy that may occur in bone. This investigation described the characteristics and outcomes of primary leiomyosarcoma of bone (PLB) compared to soft tissue leiomyosarcoma (SLMS). Methods: This study was a retrospective review using the Surveillance, Epidemiology, and End Results (SEER) database from 1975 to 2016. Continuous and categorial variables were described, and Cox regression were used to identify factors of prognostic significance. Results: Seven thousand five-hundred two patients met inclusion criteria. Seventy-four (1%) were PLB and 7428 (99%) were SLMS. On multivariable analysis for high-grade SLMS radiation (neoadjuvant: HR, 0.56; 95% CI, 0.4-0.8; p = 0.003, and adjuvant: HR, 0.75; 95% CI, 0.6-0.9; p = 0.008) and surgery (procedure specific) improved DSS, while age (HR, 1.013; 95% CI, 1.0-1.1; p < 0.001), tumor size greater than or equal to 5 cm (HR, 3.16; 95% CI, 2.3-4.2; p < 0.001), abdomen/pelvis/trunk/thorax tumors (HR, 1.31; 95% CI, 1.1-1.6; p = 0.006), and distant metastases at presentation (HR, 2.6; 95% CI, 2.1-3.3; p < 0.001) negatively influenced DSS. Conclusions: Radiation and surgery positively influence survival in high-grade SLMS while chemotherapy appears to have no benefit. Surgery alone appears to lower the mortality risk in PLB. |
| Databáze: | OpenAIRE |
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