Low-dose developmental exposure to bisphenol A alters the femoral bone geometry in wistar rats

Autor: Ulla Hass, Julie Boberg, Jan Örberg, Margareta Halin Lejonklou, L. Shen, P.M. Lind, Sofie Christiansen, Sune Larsson
Rok vydání: 2016
Předmět:
Male
0301 basic medicine
Health
Toxicology and Mutagenesis
Endocrine Disruptors
010501 environmental sciences
01 natural sciences
Absorptiometry
Photon
Bone Density
Pregnancy
Medicine
Femur
Quantitative computed tomography
medicine.diagnostic_test
General Medicine
Pollution
Biomechanical Phenomena
Endocrine disruptor
In utero
Prenatal Exposure Delayed Effects
Gestation
Female
hormones
hormone substitutes
and hormone antagonists
endocrine system
medicine.medical_specialty
Environmental Engineering
Offspring
03 medical and health sciences
Phenols
Internal medicine
Animals
Humans
Lactation
Environmental Chemistry
Endocrine system
Weaning
Benzhydryl Compounds
Rats
Wistar
0105 earth and related environmental sciences
No-Observed-Adverse-Effect Level
Bone Development
Dose-Response Relationship
Drug
urogenital system
business.industry
Public Health
Environmental and Occupational Health
General Chemistry
Rats
030104 developmental biology
Endocrinology
business
Hormone
Zdroj: Chemosphere. 164:339-346
ISSN: 0045-6535
DOI: 10.1016/j.chemosphere.2016.08.114
Popis: Background Bisphenol A (BPA) is a chemical produced in large volumes for use in manufacturing of consumer products and industrial applications, and an endocrine disruptor known to affect several hormonal systems. Bone produces hormones and is additionally a sensitive hormone target tissue, and is thus potentially sensitive to low doses of endocrine disruptors such as BPA, especially during development. Methods 110 pregnant Wistar rats were gavaged with 0; 25 μg; 250 μg; 5000 μg or 50,000 μg BPA/kg bodyweight (bw)/day from gestational day 7 until weaning at postnatal day 22. The three-month-old offspring were sacrificed and right femurs collected for length measurements, geometrical measurements by peripheral quantitative computed tomography (pQCT), as well as for analyses of biomechanical properties using the three-point-bending method. Results The femur was elongated in female offspring of dams exposed to 25 or 5000 μg BPA/kg bw/day (1.8% and 2.1%, respectively), and increased cortical thickness (4.7%) was observed in male offspring of dams exposed to 25 μg BPA/kg bw/day, compared to controls (p
Databáze: OpenAIRE
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