A Periadventitial Sirolimus-Releasing Mesh Decreased Intimal Hyperplasia in a Rabbit Model
| Autor: | M. Pařízek, Jan Pirk, Zuzana Burdikova, Eduard Brynda, Eva Filová, Jana Maluskova, A. Lytvynets, Martin Čapek, Ivo Skalský, A. Lodererová, Lucie Bacakova, V. Lisa, Ondrej Szarszoi |
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| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Intimal hyperplasia Physiology Polyesters In vivo Occlusion medicine Animals cardiovascular diseases Vein Cell Proliferation Sirolimus Neointimal hyperplasia Drug Carriers Hyperplasia business.industry Graft Occlusion Vascular Cardiovascular Agents General Medicine equipment and supplies medicine.disease Controlled release Surgery Stenosis surgical procedures operative medicine.anatomical_structure cardiovascular system Rabbits Jugular Veins Tunica Intima business medicine.drug |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1802-9973 0862-8408 |
| DOI: | 10.33549/physiolres.932106 |
| Popis: | Autologous vein grafts used as aortocoronary bypasses are often prone to intimal hyperplasia, which results in stenosis and occlusion of the vein. The aim of this study was to prevent intimal hyperplasia using a newly developed perivascular system with sustained release of sirolimus. This system of controlled drug release consists of a polyester mesh coated with a copolymer of L-lactic acid and ε-caprolactone that releases sirolimus. The mesh is intended for wrapping around the vein graft during surgery. The mesh releasing sirolimus was implanted in periadventitial position onto arteria carotis communis of rabbits, and neointimal hyperplasia was then assessed. We found that implanted sirolimus-releasing meshes reduced intima thickness by 47±10 % compared to a vein graft after 3 weeks. The pure polyester mesh decreased vein intima thickness by 35±9 %. Thus, our periadventitial system for controlled release of sirolimus prevented the development of intimal hyperplasia in autologous vein grafts in vivo in rabbits. A perivascularly applied mesh releasing sirolimus is a promising device for preventing stenosis of autologous vein grafts. |
| Databáze: | OpenAIRE |
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