Urinary catecholamine metabolites in hyperkinetic boys treated with d- amphetamine
| Autor: | James L. Chapel, Shekim Wo, Haroutune Dekirmenjian |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Male
medicine.medical_specialty Dextroamphetamine Epinephrine Hyperkinesis Normetanephrine Methoxyhydroxyphenylglycol Norepinephrine (medication) Excretion chemistry.chemical_compound Internal medicine Urinary catecholamine medicine Humans Child Medial forebrain bundle Amphetamine Metanephrine Dose-Response Relationship Drug business.industry Homovanillic acid Homovanillic Acid Psychiatry and Mental health Endocrinology chemistry Depression Chemical business medicine.drug |
| Zdroj: | American Journal of Psychiatry. 134:1276-1279 |
| ISSN: | 1535-7228 0002-953X |
| Popis: | The authors studied the excretion of 3-methoxy-4-hydroxyphenyl glycol (MHPG), normetanephrine (NM), metanephrine, and homovanillic acid in 7 hyperactive and 12 control children. MHPG was lower but NM was significantly higher in hyperactive children than in controls. Administration of d-amphetamine for 2 weeks depressed the levels of MHPG, NM, and metanephrine. The authors suggest a decreased central norepinephrine activity, which may be secondary to the interruption of norepinephrine fibers in the medial forebrain bundle. |
| Databáze: | OpenAIRE |
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