Interrelation of saturated fat, trans fat, alcohol intake, and subclinical atherosclerosis
| Autor: | Share-Ap Investigators, Salim Yusuf, Lawrence de Koning, Anwar T. Merchant, Share, Bonnie Davis, Linda E. Kelemen, Vlad Vuksan, Sonia S. Anand, Eva Lonn, Ruby Jacobs, Koon K. Teo |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Tunica media Canada medicine.medical_specialty Trans fat Alcohol Drinking Saturated fat Medicine (miscellaneous) Alcohol White People chemistry.chemical_compound Asian People Surveys and Questionnaires Internal medicine Humans Medicine Ultrasonography Interventional Aged Nutrition and Dietetics business.industry Cholesterol Middle Aged Trans Fatty Acids Atherosclerosis Tunica intima Dietary Fats Surgery Carotid Arteries Cross-Sectional Studies Endocrinology medicine.anatomical_structure chemistry Multivariate Analysis Saturated fatty acid Indians North American Female Tunica Intima Tunica Media business Artery |
| Zdroj: | The American Journal of Clinical Nutrition. 87:168-174 |
| ISSN: | 0002-9165 |
| DOI: | 10.1093/ajcn/87.1.168 |
| Popis: | Background: Intake of saturated fat, trans fat, and alcohol alter cardiovascular disease risk, but their effect on subclinical atherosclerosis remains understudied. Objective: The objective was to examine and quantify the interrelation of saturated fat, trans fat, alcohol intake, and mean carotid artery intimal medial thickness (IMT). Design: We conducted a population-based, cross-sectional study among 620 persons of Aboriginal, South Asian, Chinese, or European origin aged 35-75 y, who had lived in Canada for ≥5 y. Mean IMT was calculated from 6 well-defined segments of the right and left carotid arteries with standardized B-mode ultrasound, and saturated fat, trans fat, and alcohol intakes were measured with validated food-frequency questionnaires. Results: For every 10-g/d increase in saturated fat intake, IMT was 0.03 mm higher (P = 0.01) after multivariate adjustment. A 1-g/d higher intake of trans fat was associated with a 0.03-mm higher IMT (P = 0.02) after multivariate adjustment. The ratio of polyunsaturated to saturated fat (P:S) was inversely associated with IMT after multivariate adjustment (change in IMT: -0.06 mm; P < 0.01). Saturated and trans fat intakes were independently associated with IMT thickness (change in IMT: 0.03 mm; P < 0.01 and 0.02, respectively; P for interaction = 0.01). Polyunsaturated, monounsaturated, cholesterol, and total fat intakes were unrelated to IMT. The relation between saturated fat intake and IMT strengthened (β = 0.0066, P < 0.001) in persons who never or rarely consumed alcohol as compared with moderate or heavy drinkers (β = 0.0001, P = 0.79, P for interaction = 0.01). Conclusion: Higher habitual intakes of saturated and trans fats are independently associated with increased subclinical atherosclerosis, and alcohol intake may attenuate the relation between saturated fat and subclinical atherosclerosis. |
| Databáze: | OpenAIRE |
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