Effect of conjugated linoleic acid on bone formation and rheumatoid arthritis
| Autor: | Sun Jin Hur, Yeonhwa Park |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
Conjugated linoleic acid medicine.medical_treatment Anti-Inflammatory Agents Arthritis Bone resorption Proinflammatory cytokine Arthritis Rheumatoid chemistry.chemical_compound Osteogenesis Internal medicine medicine Animals Humans Linoleic Acids Conjugated Pharmacology Calcium metabolism Inflammation integumentary system biology Chemistry food and beverages medicine.disease Endocrinology Cytokine Rheumatoid arthritis biology.protein Cytokines lipids (amino acids peptides and proteins) Cyclooxygenase |
| Zdroj: | European journal of pharmacology. 568(1-3) |
| ISSN: | 0014-2999 |
| Popis: | Conjugated linoleic acid (CLA) has shown a variety of biologically beneficial effects. Dietary CLA inhibits eddosteal bone resorption, increases endocortical bone formation, and modulates the action and expression of cyclooxygenase (COX) enzyme, thereby decreasing prostaglandin-dependent bone resorption. CLA also enhances calcium absorption and may improve bone formation in animals, although results are not consistent. Since CLA can also affect inflammatory cytokines, it is hypothesized that CLA may be a good tool for prevention or reduction of rheumatoid arthritis symptoms. The possible mechanisms by which CLA prevents rheumatoid arthritis as well as other inflammatory diseases is discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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