Chronic therapeutic anticoagulation is associated with decreased thrombotic complications in SARS‐CoV‐2 infection
| Autor: | Stephen Rappaport, Daniel J. Lachant, Paritosh Prasad, Peter Kouides, Neil A. Lachant, R. James White |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) New York Hemorrhage 030204 cardiovascular system & hematology Single Center 03 medical and health sciences 0302 clinical medicine Pharmacotherapy Disease severity Risk Factors Intensive care Internal medicine medicine Humans Aged Retrospective Studies Aged 80 and over SARS-CoV-2 business.industry Anticoagulants COVID-19 Thrombosis Retrospective cohort study Hematology medicine.disease COVID-19 Drug Treatment Female business Thrombotic complication |
| Zdroj: | Journal of Thrombosis and Haemostasis |
| ISSN: | 1538-7836 |
| Popis: | Background Thrombotic disease complicates severe SARS-CoV-2 infection and is associated with increased morbidity and mortality Various anticoagulation strategies have been evaluated in hospitalized patients to prevent complications The impact of chronic anticoagulation prior to SARS-CoV-2 infection on the risk for subsequent thrombosis has not been systematically studied Methods This was a retrospective single center study All patients with positive SARS-CoV-2 PCR testing from March 13, 2020 through May 6, 2020 at the University of Rochester Medical Center were identified We included all patients receiving therapeutic anticoagulation for at least one month prior to COVID diagnosis We documented the rate of thrombotic complications, type of anticoagulation, bleeding complications, and mortality Results A total of 107 SARS-CoV2 infected patients were chronically anticoagulated before SARS-CoV-2 testing with a median age of 78 Of those, 42 required hospital admission with 17 requiring intensive care No patients, inpatient or outpatient, were diagnosed with a new symptomatic thrombotic complication Three patients had minor bleeding in the hospital Thirteen (12%) patients died (69% male) Conclusion Our uncontrolled findings suggest that chronic anticoagulation at the time of infection may protect against thrombotic complications and decrease disease severity |
| Databáze: | OpenAIRE |
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