926-23 Endocardial Mapping in Patients with the Hereditary Long QT Syndrome
| Autor: | Martin Höher, T. Eggeling, Hans Osterhues |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
Diagnostic information
medicine.medical_specialty congenital hereditary and neonatal diseases and abnormalities business.industry Long QT syndrome Propranolol Age and sex medicine.disease Orciprenaline Pathognomonic Internal medicine Cardiology Medicine In patient cardiovascular diseases business Cardiology and Cardiovascular Medicine medicine.drug |
| Zdroj: | Journal of the American College of Cardiology. (2):107A |
| ISSN: | 0735-1097 |
| DOI: | 10.1016/0735-1097(95)91897-7 |
| Popis: | Endocardial right and left ventricular mapping was performed in n = 12 patients with the Long QT Syndrome (LQTS) to determine the presence of my-ocardial microvolt potentials (MMP) within the ST-T segment and after the T-wave. The findings were compared with those obtained in n = 12 age and sex matched WPW patients, who served as control group. Mapping was performed without medication (baseline), and after Orciprenaline (0.01 mg/kg i.v.) and Propranolol 0.013 mg/kg i.v.). LQTS Control P QTc-duration Baseline 479 ± 41 ms 395 ± 29 ms l0.01 Orciprenaline 494 ± 43 ms 386 ± 24 ms l0.01 Propranolol 461 ± 48 ms 397 ± 26 ms l0.01 MMP Baseline n = 3 n = 0 NS Orciprenaline n = 12 n = 0 l0.01 Propranolol n = 0 n = 0 NS MMP could be detected in all LQTS patients after administration of Orciprenaline, no MMP could be induced in the WPW group. We consider MMP in LQTS patients to be an evidence of early after depolarizations. This finding could be pathognomonic for LQTS patients. Thus, endocardial mapping may contribute important diagnostic information in patients with suspected LQTS. |
| Databáze: | OpenAIRE |
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