Expression of MMP-2, MMP-9, and NGAL in Tissue and Serum of Patients with Vascular Aneurysms and Their Modulation by Statin Treatment: A Pilot Study
| Autor: | Federica Colosimo, Maria Cristina Caroleo, Luca Gallelli, Elena Piegari, Erika Cione, Giuseppe Gallelli, Francesca Curcio, Stefano de Franciscis, Manuela Colosimo, Elena Lamirata, Nicola Ielapi, Roberto Cannataro |
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| Přispěvatelé: | Cione, Erika, Piegari, Elena, Gallelli, Giuseppe, Caroleo, Maria Cristina, Lamirata, Elena, Curcio, Francesca, Colosimo, Federica, Cannataro, Roberto, Ielapi, Nicola, Colosimo, Manuela, Franciscis, Stefano de, Gallelli, Luca |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Group ii lcsh:QR1-502 Pilot Projects 030204 cardiovascular system & hematology Lipocalin Matrix metalloproteinase Biochemistry Gastroenterology patients Article lcsh:Microbiology statins 03 medical and health sciences 0302 clinical medicine Lipocalin-2 Western blot Internal medicine arterial aneurysms Humans Medicine Potency Prospective Studies cardiovascular diseases NGAL Molecular Biology Aged medicine.diagnostic_test MMP business.industry arterial aneurysm MMPs Plasma levels Middle Aged Statin treatment Aneurysm Matrix Metalloproteinase 9 030220 oncology & carcinogenesis Elisa test Matrix Metalloproteinase 2 Female patient Hydroxymethylglutaryl-CoA Reductase Inhibitors business |
| Zdroj: | Biomolecules Volume 10 Issue 3 Biomolecules, Vol 10, Iss 3, p 359 (2020) |
| ISSN: | 2218-273X |
| DOI: | 10.3390/biom10030359 |
| Popis: | Background: Matrix metalloproteinases (MMPs) are involved in vascular wall degradation, and drugs able to modulate MMP activity can be used to prevent or treat aneurysmal disease. In this study, we evaluated the effects of statins on MMP-2, MMP-9, and neutrophil gelatinase-associated lipocalin (NGAL) in both plasma and tissue in patients with aneurysmal disease. Methods: We performed a prospective, single-blind, multicenter, control group clinical drug trial on 184 patients of both sexes > 18 years old with a diagnosis of arterial aneurysmal disease. Enrolled patients were divided into two groups: Group I under statin treatment and Group II not taking statins. In addition, 122 patients without aneurysmal disease and under statin treatment were enrolled as a control group (Group III). The expression of MMPs and NGAL in plasma was evaluated using ELISA, while their expression in endothelial tissues was evaluated using Western blot. Results: The ELISA test revealed greater plasma levels (p < 0.01) of MMPs and NGAL in Groups I and II vs. Group III. Western blot analysis showed higher expression (p < 0.01) of MMPs and NGAL in Group II vs. Group I, and this increase was significantly higher (p < 0.01) in patients treated with low potency statins compared to high potency ones. Conclusions: MMPs and NGAL seem to play a major role in the development of aneurysms, and their modulation by statins suggests that these drugs could be used to prevent arterial aneurysmal disease. |
| Databáze: | OpenAIRE |
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