Effects of immune complexes from SLE patients on human monocyte locomotion and Fc receptor function
| Autor: | I. Sonkoly, Mária Kávai, Eva Vegh, Gyula Szegedi, Katalin Lukács, Anikó Bányai, Gyongyi Szabo |
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| Rok vydání: | 1984 |
| Předmět: |
Male
Low protein Rosette Formation Monocyte chemotaxis Immunology Fc receptor Enzyme-Linked Immunosorbent Assay Antigen-Antibody Complex Receptors Fc General Biochemistry Genetics and Molecular Biology Immunoglobulin G Monocytes Immune system Glomerulonephritis Rheumatology Immunology and Allergy Medicine Humans Lupus Erythematosus Systemic biology business.industry Monocyte Chemotaxis Complement C3 medicine.disease Chemotaxis Leukocyte medicine.anatomical_structure Antibodies Antinuclear biology.protein Female business Nephritis Research Article |
| Zdroj: | Annals of the rheumatic diseases. 43(5) |
| ISSN: | 0003-4967 |
| Popis: | The effect of immune complexes (IC) isolated from systemic lupus erythematosus (SLE) sera with polyethylene glycol and gel filtration on the chemotaxis and Fc receptor function of healthy monocytes was examined. Even at a low protein concentration (1 microgram/ml = 1 mg/l) ICs inhibit monocyte chemotaxis. ICs from patients with SLE nephritis are more inhibitory than ICs from patients without renal disease. The inhibitory effects of ICs on monocyte chemotaxis and Fc receptor activity are similar, suggesting a relationship between the chemotactic and Fc receptor function of monocytes. Analysis of the ICs by enzyme-linked immunoassay showed no correlation between the quantity of IgG, C3, and anti-DNA in the IC samples and their effects on monocyte function. |
| Databáze: | OpenAIRE |
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