Treadmill exercise improves spatial learning ability by increasing cell proliferation in offspring born to maternal rats receiving stress during pregnancy
| Autor: | Ki-Hyok Youn, Young Jun Ko, Sam-Jun Lee, Boo-Geun Hwang, Tae-Woon Kim, Hyun-Seok Bang |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
030506 rehabilitation
medicine.medical_specialty Maternal stress Offspring Physical Therapy Sports Therapy and Rehabilitation Apoptosis Tropomyosin receptor kinase B Brain-derived neurotrophic factor 03 medical and health sciences 0302 clinical medicine Neurotrophic factors Internal medicine Spatial learning ability Medicine Hippocampus (mythology) Orthopedics and Sports Medicine Cell proliferation Pregnancy business.industry Neurogenesis 030229 sport sciences medicine.disease Endocrinology Prenatal stress Treadmill exercise Original Article 0305 other medical science business |
| Zdroj: | Journal of Exercise Rehabilitation |
| ISSN: | 2288-1778 2288-176X |
| Popis: | Prenatal stress causes learning deficits by inhibiting neurogenesis in the hippocampus. We studied the effects of maternal treadmill running or offspring treadmill running on the spatial learning ability of adolescent offspring rats or adult offspring rats born to maternal rats that received stress during pregnancy. For this study, spatial learning ability was measured by radial 8-arm maze task. Immunohistochemistry for 5-bromo-2'-deoxyuridine and Western blot for brain-derived neurotrophic factor (BDNF), tyrosine kinase B (TrkB), Bcl-2-associated X protein (Bax), and B-cell lymphoma 2 (Bcl-2) were also conducted. Stress was induced by exposing pregnant rats to hound in an enclosed room. Maternal treadmill running or treadmill running of offspring improved spatial learning ability of adolescent and adult offspring rats born to maternal rats receiving stress during pregnancy. Maternal treadmill running or treadmill running of offspring increased hippocampal cell proliferation of adolescent and adult offspring rats born to maternal rats receiving stress during pregnancy. Maternal treadmill running or treadmill running of offspring increased BDNF and TrkB expression in the hippocampus of adolescent and adult offspring rats born to maternal rats receiving stress during pregnancy. Maternal treadmill running or treadmill running of offspring inhibited Bax expression and increased Bcl-2 expression in the hippocampus of adolescent and adult offspring rats born to maternal rats receiving stress during pregnancy. Mother's exercise during pregnancy or child's exercise after childbirth can improve the spatial learning ability deteriorated due to stress during pregnancy. |
| Databáze: | OpenAIRE |
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