CO binding to hemoglobin and myoglobin in equilibrium with a gas phase of low PO2 value
| Autor: | L. Sabbioneda, Angelo Agostoni, M. Perrella, U. Zoni |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
inorganic chemicals
Carbon Monoxide Myoglobin Physiology Chemistry Oxygen metabolism Analytical chemistry In Vitro Techniques Gas phase Oxygen Hemoglobins chemistry.chemical_compound Carboxyhemoglobin Physiology (medical) Torr cardiovascular system Humans Hemoglobin CO binding circulatory and respiratory physiology |
| Zdroj: | Journal of Applied Physiology. 65:2513-2517 |
| ISSN: | 1522-1601 8750-7587 |
| DOI: | 10.1152/jappl.1988.65.6.2513 |
| Popis: | The aim of this paper was to measure the binding of CO to myoglobin and hemoglobin at various PO2 values. For this purpose we have studied an "in vitro" system made up of solutions of hemoglobin and myoglobin equilibrated in two connected tonometers with the same gas phase of various PO2 and PCO. The results indicate that a significant proportion of CO is released by hemoglobin and binds myoglobin at low PO2 values (approximately 2-3 Torr), in qualitative agreement with the predictions of a previous computer simulation of the "in vivo" system. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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