Enhancement of Commercial Antifungal Agents by Kojic Acid
| Autor: | Jong H. Kim, Natália C G Faria, Kathleen L. Chan, Noreen Mahoney, Young K Kim, Maria de L. Martins, Perng-Kuang Chang, Bruce C. Campbell |
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| Přispěvatelé: | Instituto de Higiene e Medicina Tropical (IHMT) |
| Rok vydání: | 2012 |
| Předmět: |
Antifungal Agents
Chemosensitizer hydrogen peroxide Microbial Sensitivity Tests Aspergillosis Article Catalysis strobilurin Aspergillus fumigatus Microbiology Inorganic Chemistry lcsh:Chemistry chemistry.chemical_compound Kojic acid Disk Diffusion Antimicrobial Tests Yeasts Amphotericin B medicine Strobilurin Humans Physical and Theoretical Chemistry amphotericin B chemosensitization Molecular Biology lcsh:QH301-705.5 Spectroscopy Biological Products biology Organic Chemistry Fungi Drug Synergism General Medicine biology.organism_classification medicine.disease Computer Science Applications Fungicide Biochemistry chemistry lcsh:Biology (General) lcsh:QD1-999 Pyrones Fermentation medicine.drug |
| Zdroj: | International Journal of Molecular Sciences; Volume 13; Issue 11; Pages: 13867-13880 International Journal of Molecular Sciences, Vol 13, Iss 11, Pp 13867-13880 (2012) Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP International Journal of Molecular Sciences |
| Popis: | Natural compounds that pose no significant medical or environmental side effects are potential sources of antifungal agents, either in their nascent form or as structural backbones for more effective derivatives. Kojic acid (KA) is one such compound. It is a natural by-product of fungal fermentation commonly employed by food and cosmetic industries. We show that KA greatly lowers minimum inhibitory (MIC) or fungicidal (MFC) concentrations of commercial medicinal and agricultural antifungal agents, amphotericin B (AMB) and strobilurin, respectively, against pathogenic yeasts and filamentous fungi. Assays using two mitogen-activated protein kinase (MAPK) mutants, i.e., sakA∆, mpkC∆, of Aspergillus fumigatus, an agent for human invasive aspergillosis, with hydrogen peroxide (H2O2) or AMB indicate such chemosensitizing activity of KA is most conceivably through disruption of fungal antioxidation systems. KA could be developed as a chemosensitizer to enhance efficacy of certain conventional antifungal drugs or fungicides. |
| Databáze: | OpenAIRE |
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