Rutin ameliorates methotrexate induced hepatic injury in rats
| Autor: | Emin Oztas, Turgut Topal, Pınar Naile Gürgör, Yesim Oztas, Esra Erdogan, Yasin Ilgaz |
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| Rok vydání: | 2015 |
| Předmět: |
musculoskeletal diseases
RD1-811 Rutin medicine.medical_treatment Drug Effects Pharmacology medicine.disease_cause Antioxidants Superoxide dismutase chemistry.chemical_compound Malondialdehyde medicine Animals Aspartate Aminotransferases Rats Wistar skin and connective tissue diseases chemistry.chemical_classification Glutathione Peroxidase biology Superoxide Dismutase business.industry Glutathione peroxidase Reproducibility of Results Alanine Transaminase Rats Oxidative Stress Methotrexate Liver chemistry Alanine transaminase Immunology biology.protein Female Surgery Chemical and Drug Induced Liver Injury business Adjuvant Immunosuppressive Agents Oxidative stress medicine.drug |
| Zdroj: | Acta Cirúrgica Brasileira v.30 n.11 2015 Acta Cirúrgica Brasileira Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC Acta Cirurgica Brasileira, Volume: 30, Issue: 11, Pages: 778-784, Published: NOV 2015 Acta Cirurgica Brasileira, Vol 30, Iss 11, Pp 778-784 (2015) |
| ISSN: | 0102-8650 |
| Popis: | PURPOSE: To investigate the possible protective effect of rutin on methotrexate induced hepatotoxicity in rats. METHODS: Twenty-two rats were divided into three experimental groups; Control-saline, Mtx, Mtx+Rutin. Hepatic tissue was taken for histological assessment and biochemical assays. Oxidative stress parameters malondialdehyde (MDA), glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) were investigated. Liver markers aspartate aminotransferase (AST), alanine aminotransferase (ALT) were analyzed in serum. RESULTS: Mtx+Rutin group showed lower histological injury compared to Mtx group, MDA and ALT levels were increased, while SOD and GSH-Px were decreased in Mtx group compared with Control-saline group. MDA and ALT levels were increased, while SOD and GSH-Px were decreased in Mtx group, compared with Mtx +Rutin group. Serum AST levels were similar among the groups. CONCLUSION: Rutin may be a potential adjuvant drug to reduce the hepatic side effects observed during Mtx therapy for various clinical conditions. |
| Databáze: | OpenAIRE |
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