Etiology and Outcome of Candidemia in Neonates and Children in Europe: An 11-year Multinational Retrospective Study
Autor: | Warris, A., Pana, Z.D., Oletto, A., Lundin, R., Castagnola, E., Lehrnbecher, T., Groll, A.H., Roilides, E., Andersen, C.T., Arendrup, M.C., Arsenijevic, V.A., Bianchini, S., Both, U. von, Chmelnik, M., Controzzi, T., Emonts, M., Esposito, S., Ferreras-Antolin, L., Henriet, S.S., Iosifidis, E., Irwin, A., Kopsidas, J., Lagrou, K., Lyall, H., Casteleiro, A.M., Mesini, A., Olbrich, P., Paulus, S., Lausch, K.R., Soler-Palacin, P., Spyridis, N., Strenger, V., Theodoraki, M., Wolfs, T. |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Microbiology (medical)
medicine.medical_specialty lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4] Candida parapsilosis 03 medical and health sciences [**EUROCANDY study group] 0302 clinical medicine children 030225 pediatrics Internal medicine Epidemiology medicine 030212 general & internal medicine Candida albicans Candida spp biology infants business.industry candidemia Postmenstrual Age Retrospective cohort study Odds ratio biology.organism_classification neonates Confidence interval Infectious Diseases EUROCANDY Study Group Pediatrics Perinatology and Child Health Etiology business |
Zdroj: | Pediatric Infectious Disease Journal, 39, 2, pp. 114-120 Warris, A, Pana, Z D, Oletto, A, Lundin, R, Castagnola, E, Lehrnbecher, T, Groll, A H, Roilides, E, Andersen, C T, Arendrup, M C, Arsenijevic, V A, Bianchini, S, Von Both, U, Chmelnik, M, Controzzi, T, Emonts, M, Esposito, S, Ferreras-Antolin, L, Henriet, S, Iosifidis, E, Irwin, A, Kopsidas, J, Lagrou, K, Lyall, H, Casteleiro, A M, Mesini, A, Olbrich, P, Paulus, S, Lausch, K R, Soler-Palacin, P, Spyridis, N, Strenger, V, Theodoraki, M & Wolfs, T 2020, ' Etiology and Outcome of Candidemia in Neonates and Children in Europe : An 11-year Multinational Retrospective Study ', Pediatric Infectious Disease Journal, vol. 39, no. 2, pp. 114-120 . https://doi.org/10.1097/INF.0000000000002530 Pediatric Infectious Disease Journal, 39, 114-120 |
ISSN: | 0891-3668 |
DOI: | 10.1097/INF.0000000000002530 |
Popis: | BACKGROUND: Data on Candida bloodstream infections in pediatric patients in Europe are limited. We performed a retrospective multicenter European study of the epidemiology and outcome of neonatal and pediatric candidemia. MATERIAL AND METHODS: All first positive blood cultures from patients ≤ 18 years of age with candidemia were registered. Patients' demographic and clinical characteristics and causative Candida species were collected and analyzed. Regression analysis was used to identify factors independently associated with mortality. RESULTS: One thousand three hundred ninety-five episodes of candidemia (57.8% male) were reported from 23 hospitals in 10 European countries. Of the 1395 episodes, 36.4% occurred in neonates (≤ 44 weeks postmenstrual age), 13.8% in infants (> 44 weeks postmenstrual age to 1 year) and 49.8% in children and adolescents. Candida albicans (52.5%) and Candida parapsilosis (28%) were the predominant species. A higher proportion of candidemia caused by C. albicans was observed among neonatal patients (60.2%) with highest rates of C. parapsilosis seen among infants (42%). Children admitted to hematology-oncology wards presented the highest rates of non-albicans Candida species. Candidemia because of C. albicans was more frequent than non-albicans Candida in Northern versus Southern Europe (odds ratio, 2.3; 95% confidence interval, 1.8-2.9; P < 0.001). The all-cause mortality at 30 days was 14.4%. All-cause mortality was higher among patients admitted to the neonatal or pediatric intensive care units than other wards. Over time, no significant changes in species distribution were observed. CONCLUSIONS: This first multicenter European study shows unique characteristics of the epidemiology of pediatric candidemia. The insights obtained from this study will be useful to guide clinical management and antifungal stewardship. ispartof: Pediatr Infect Dis J vol:39 issue:2 pages:114-120 ispartof: location:United States status: published |
Databáze: | OpenAIRE |
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