Associations Between Diabetes and Idiopathic Pulmonary Fibrosis: a Study-level Pooled Analysis of 26 Million People
| Autor: | Zubing Mei, Zhiguang Zhou, Yang Xiao, Jianru Yan, Zhuo-Wei Hu, Chenyu Li, Jingyi Hu |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Systemic disease Endocrinology Diabetes and Metabolism Clinical Biochemistry Context (language use) Cochrane Library Biochemistry Idiopathic pulmonary fibrosis Endocrinology Diabetes mellitus Internal medicine medicine Diabetes Mellitus Prevalence Humans Prospective cohort study Lung business.industry Biochemistry (medical) Odds ratio respiratory system medicine.disease Prognosis Idiopathic Pulmonary Fibrosis respiratory tract diseases medicine.anatomical_structure business |
| Zdroj: | The Journal of clinical endocrinology and metabolism. 106(11) |
| ISSN: | 1945-7197 |
| Popis: | Context Diabetes mellitus (DM) is a systemic disease characterized by chronic hyperglycemia associated with inflammation and oxidative stress, and the lung may be a target organ of diabetic microvascular damage. Several studies have indicated a positive association between idiopathic pulmonary fibrosis (IPF) and diabetes with controversial findings. Objective Primary outcomes were to compare the prevalence of DM among individuals with IPF to non-IPF controls, and the prevalence of IPF among individuals with DM to non-DM controls. Methods Data sources include PubMed, EMBASE, and the Cochrane Library. Studies contained sufficient data to calculate the prevalence of DM among individuals with and without IPF, or the prevalence of IPF among individuals with and without DM. Two investigators independently identified eligible studies and extracted data. Pooled odds ratio (OR) with 95% CI was the summary effect measure. Results Eighteen studies including 26 410 623 individuals met the eligibility criteria, of whom 16 recruited people with IPF and 2 recruited people with DM. The OR of DM in IPF patients was 1.54 (95% CI, 1.30-1.84; P Conclusion This meta-analysis suggests that people with IPF have 1.54 times increased odds of diabetes compared to non-IPF controls, while whether patients with DM have an increased risk of IPF is still controversial. Further large, prospective cohort studies investigating the prevalence of IPF in diabetic patients are warranted. |
| Databáze: | OpenAIRE |
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