Treatment of cutaneous granulocytic sarcoma in a patient with myelodysplasia
| Autor: | Bernett L. Johnson, Janet H. Prystowsky, Brian J. Bolwell, Geralds S. Lazarus |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Male
Acute leukemia Chemotherapy medicine.medical_specialty Leg Skin Neoplasms business.industry medicine.medical_treatment H&E stain General Medicine Middle Aged medicine.disease Dermatology Combined Modality Therapy Amputation Surgical Radiation therapy Leukemia Amputation Leukemia Myeloid Myelodysplastic Syndromes medicine Humans Sarcoma business |
| Zdroj: | The American journal of medicine. 86(4) |
| ISSN: | 0002-9343 |
| Popis: | In this report, we have presented our experience with a patient with a rare cutaneous granulocytic sarcoma. In addition to hematoxylin and eosin, myeloperoxidase stain and specific stains for lysozyme and esterase were helpful in confirming the histologic diagnosis of granulocytic sarcoma. Despite multiple attempts to control this patient's tumor by conservative surgery, radiation therapy, and chemotherapy, we eventually had to resort to limb amputation. This procedure restored a meaningful quality of life to this patient for one and a half years prior to the development of acute leukemia. Treatment with corticosteroids at the time of surgery may have prevented a local recurrence of granulocytic sarcoma despite positive tissue margins. Our experience underscores the importance of directing treatment toward the granulocytic sarcoma whereas the myelodysplasia concurrently present may not require therapy for several years. |
| Databáze: | OpenAIRE |
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