Prunella vulgaris: A Comprehensive Review of Chemical Constituents, Pharmacological Effects and Clinical Applications
| Autor: | Khalid Rahman, Hua Nian, Yuan-Yuan Dai, Su-Juan Wang, Ming-Hua Ma, Hong Zhang, Xiao-He Wang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Pharmacology
0303 health sciences RM Asia Plants Medicinal Traditional medicine Plant Extracts Prunella vulgaris Phytochemicals food and beverages RV Perennial herb Biology biology.organism_classification 03 medical and health sciences 0302 clinical medicine Triterpenoid 030220 oncology & carcinogenesis Labiate family Chemical constituents Drug Discovery Asian country Prunella Pv plant 030304 developmental biology |
| Zdroj: | Current pharmaceutical design. 25(3) |
| ISSN: | 1873-4286 1381-6128 |
| Popis: | Prunella vulgaris (PV) is a perennial herb belonging to the Labiate family and is widely distributed in the northeastern Asian countries such as Korea, Japan, and China. It is reported to display diverse biological activities including anti-microbial, anti-cancer, and anti-inflammation as determined by in vitro or in vivo studies. So far, about 200 compounds have been isolated from PV plant and a majority of these have been characterized mainly as triterpenoids, sterols and flavonoids, followed by coumarins, phenylpropanoids, polysaccharides and volatile oils. This review summarizes and analyzes the current knowledge on the chemical constituents, pharmacological activities, mechanisms of action and clinical applications of the PV plant including its potential as a future medicinal plant. Although some of the chemical constituents of the PV plant and their mechanisms of action have been investigated, the biological activities of many of these remain unknown and further clinical trials are required to further enhance its reputation as a medicinal plant. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|