Evaluation of extensively drug-resistant gram-negative bacteremia among solid-organ transplant recipients: a multicenter study
| Autor: | Ebru Kurşun, Alpay Ari, Yasemin Tezer Tekçe, Adem Kose, Tugba Yanik Yalcin, Filiz Kizilates, Secil Deniz, Oya Özlem Eren Kutsoylu, Yurdagül Albayrak, Selçuk Özger, Özlem Kurt Azap, Hikmet Eda Alışkan, Hatice Çabadak, Tufan Egeli, Özlem Güzel Tunçcan, Mehmet Haberal, Güle Çınar, Yesim Uygun Kizmaz, Yasar Bayindir, Kübra Demir Önder, Elif Mukime Saricaoglu |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Multivariate analysis drug-resistant Blood-Stream Infection Bacteremia Drug resistance Outcomes Risk Factors Internal medicine Drug Resistance Multiple Bacterial Gram-Negative Bacteria Medicine Humans Risk factor Aged Retrospective Studies Lung business.industry Mortality rate Retrospective cohort study General Medicine Organ Transplantation Middle Aged medicine.disease Transplant Recipients Anti-Bacterial Agents Transplantation medicine.anatomical_structure Liver Female Solid-organ transplant recipients business Gram-Negative Bacterial Infections |
| Popis: | Background/aim: The aim of this study is to evaluate the distribution, sources, clinical features, and mortality rates of bacteremia due to evaluation of extensively drug-resistant (XDR) gram negative among solid-organ transplant (SOT) recipients. Materials and methods: A retrospective study of SOT recipients with bacteremia due to XDR gram-negative pathogens in 11 centers between 2016 and 2018 was conducted. Patients' records were evaluated. Results: Of 171 bacteremia that occurred in 164 SOT recipients, 93 (56.7%) were liver, 46 (28%) kidney, 14 (8.5%) heart, and 11 (6.7%) lung recipients. Bacteremia episodes were recorded in the first year in 63.7% of the patients (n = 109), early-onset bacteremia was recorded in 45% (n = 77) of the episodes. In multivariate analysis, catheter-associated bacteremia was an independent risk factor for 7-day mortality (p = 0.037), and early-onset bacteremia was found as an independent risk factor for 30-day mortality (p = 0.017). Conclusion: Difficult-to-treat infections due to XDR bacteria in SOT recipients shadow the success of transplantation. Central venous catheters seem to be the main risk factor. Judicious use of medical devices is of pivotal importance. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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