Neural mechanisms underlying GABAergic regulation of adult hippocampal neurogenesis
| Autor: | Christina M. Catavero, Hechen Bao, Juan Song |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
0301 basic medicine Cell type Histology Neurogenesis Biology Hippocampal formation Article Pathology and Forensic Medicine Subgranular zone Mice 03 medical and health sciences 0302 clinical medicine Neural Stem Cells Receptors GABA Central Nervous System Diseases Interneurons medicine Animals Humans GABAergic Neurons gamma-Aminobutyric Acid Dentate gyrus Cell Biology Neural stem cell Neuroepithelial cell Disease Models Animal 030104 developmental biology medicine.anatomical_structure nervous system Dentate Gyrus GABAergic Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Cell and Tissue Research. 371:33-46 |
| ISSN: | 1432-0878 0302-766X |
| DOI: | 10.1007/s00441-017-2668-y |
| Popis: | Within the dentate gyrus of the adult hippocampus is the subgranular zone, which contains a neurogenic niche for radial-glia like cells, the most primitive neural stem cells in the adult brain. The quiescence of neural stem cells is maintained by tonic gamma-aminobutyric acid (GABA) released from local interneurons. Once these cells differentiate into neural progenitor cells, GABA continues to regulate their development into mature granule cells, the principal cell type of the dentate gyrus. Here, we review the role of GABA circuits, signaling, and receptors in regulating development of adult-born cells, as well as the molecular players that modulate GABA signaling. Furthermore, we review recent findings linking dysregulation of adult hippocampal neurogenesis to the altered GABAergic circuitry and signaling under various pathological conditions. |
| Databáze: | OpenAIRE |
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