Study to Investigate the anti-inflammatory effect of Codelac® Broncho with Thymus Serpyllum (elixir) in comparison with reference drug Fenspiride (syrup) using accute Carrageenan-induced Paw Inflammation Model
| Autor: | Anna A. Peresypkina, Elena N. Kareva, Pavel D. Kolesnichenko, Artem A. Poromov, Alexey N. Demidenko, Alexey V. Tverskoi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.drug_class
Fenspiride 02 engineering and technology RM1-950 acute exudative inflammation Paw inflammation Anti-inflammatory 03 medical and health sciences chemistry.chemical_compound medicine Pharmacology (medical) Codelac® Broncho with Thymus Serpyllum (elixir) carrageenan edema anti-inflammatory activity 030304 developmental biology Pharmacology 0303 health sciences biology Traditional medicine Chemistry 021001 nanoscience & nanotechnology biology.organism_classification Reference drug Elixir Thymus serpyllum Carrageenan Therapeutics. Pharmacology 0210 nano-technology medicine.drug |
| Zdroj: | Research Results in Pharmacology, Vol 5, Iss 1, Pp 45-52 (2019) Research Results in Pharmacology 5(1): 45-52 |
| Popis: | Introduction: Evaluation of anti-inflammatory action of Codelac® Broncho with Thymus Serpyllum (elixir) in comparison with Fenspiride was carried out on the model of acute carrageenan inflammation of the paws in rats. Materials and methods: Edema was caused by subplantar injection of 0.1 ml of 1% λ- carrageenan gel into the hind paw. The severity of edema was assessed by using 37140 plethysmometer (UGO BASILE, Italy). The measurements were performed before edema induction and 1, 2, 4, 12, 24, 48, 72, 96 and 120 hours afterwards. Anti-inflammatory activity of the drugs was also evaluated based on the analysis of rats’ blood, C-reactive protein concentration and histological examination results. Results and discussion: A decrease in the paw volume increment was revealed in the group with the studied drug in comparison with the group with the carrageenan edema model (control) 4, 12, 24 hours after injection of carrageenan (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|