The Degree of Nesting between Spindles and Slow Oscillations Modulates Neural Synchrony
| Autor: | Daniel Egert, Daniel B. Silversmith, Karunesh Ganguly, Joshua D. Berke, Stefan M. Lemke |
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| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine 1.1 Normal biological development and functioning Population Local field potential Biology spiking Basic Behavioral and Social Science Medical and Health Sciences 03 medical and health sciences slow waves 0302 clinical medicine Clinical Research Underpinning research Behavioral and Social Science Neuroplasticity Animals sleep education Research Articles Memory Consolidation Neurons education.field_of_study Neurology & Neurosurgery General Neuroscience Psychology and Cognitive Sciences Motor Cortex slow oscillations Neurosciences Electroencephalography spindle Neurophysiology Brain Waves Degree (music) Rats 030104 developmental biology correlation Neurological Nesting (computing) Memory consolidation Sleep Stages Primary motor cortex Sleep Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | The Journal of neuroscience : the official journal of the Society for Neuroscience, vol 40, iss 24 J Neurosci |
| ISSN: | 1529-2401 0270-6474 |
| DOI: | 10.1523/jneurosci.2682-19.2020 |
| Popis: | Spindles and slow oscillations (SOs) both appear to play an important role in memory consolidation. Spindle and SO “nesting,” or the temporal overlap between the two events, is believed to modulate consolidation. However, the neurophysiological processes modified by nesting remain poorly understood. We thus recorded activity from the primary motor cortex of 4 male sleeping rats to investigate how SO and spindles interact to modulate the correlation structure of neural firing. During spindles, primary motor cortex neurons fired at a preferred phase, with neural pairs demonstrating greater neural synchrony, or correlated firing, during spindle peaks. We found a direct relationship between the temporal proximity between SO and spindles, and changes to the distribution of neural correlations; nesting was associated with narrowing of the distribution, with a reduction in low- and high-correlation pairs. Such narrowing may be consistent with greater exploration of neural states. Interestingly, after animals practiced a novel motor task, pairwise correlations increased during nested spindles, consistent with targeted strengthening of functional interactions. These findings may be key mechanisms through which spindle nesting supports memory consolidation. SIGNIFICANCE STATEMENT Our analysis revealed changes in cortical spiking structure that followed the waxing and waning of spindles; firing rates increased, spikes were more phase-locked to spindle-band local field potential, and synchrony across units peaked during spindles. Moreover, we showed that the degree of nesting between spindles and slow oscillations modified the correlation structure across units by narrowing the distribution of pairwise correlations. Finally, we demonstrated that engaging in a novel motor task increased pairwise correlations during nested spindles. These phenomena suggest key mechanisms through which the interaction of spindles and slow oscillations may support sensorimotor learning. More broadly, this work helps link large-scale measures of population activity to changes in spiking structure, a critical step in understanding neuroplasticity across multiple scales. |
| Databáze: | OpenAIRE |
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