Transgenic mouse models of breast cancer
| Autor: | Hui-Wen Lo, Grace L. Wong, Angelina T. Regua, Austin Arrigo, Daniel Doheny |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Genetically modified mouse Cancer Research Carcinogenesis Transgene Mammary gland Breast Neoplasms Mice Transgenic Biology medicine.disease_cause Article 03 medical and health sciences Mammary Glands Animal 0302 clinical medicine Breast cancer medicine Animals Humans Mammary Neoplasms Experimental Cancer medicine.disease Disease Models Animal 030104 developmental biology medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Genetically Engineered Mouse Knockout mouse Cancer research Female |
| Zdroj: | Cancer Lett |
| ISSN: | 0304-3835 |
| DOI: | 10.1016/j.canlet.2021.05.027 |
| Popis: | Transgenic breast cancer mouse models are critical tools for preclinical studies of human breast cancer. Genetic editing of the murine mammary gland allows for modeling of abnormal genetic events frequently found in human breast cancers. Genetically engineered mouse models (GEMMs) of breast cancer employ tissue-specific genetic manipulation for tumorigenic induction within the mammary tissue. Under the transcriptional control of mammary-specific promoters, transgenic mouse models can simulate spontaneous mammary tumorigenesis by expressing one or more putative oncogenes, such as MYC, HRAS, and PIK3CA. Alternatively, the Cre-Lox system allows for tissue-specific deletion of tumor suppressors, such as p53, Rb1, and Brca1, or specific knock-in of putative oncogenes. Thus, GEMMs can be designed to implement one or more genetic events to induce mammary tumorigenesis. Features of GEMMs, such as age of transgene expression, breeding quality, tumor latency, histopathological characteristics, and propensity for local and distant metastasis, are variable and strain-dependent. This review aims to summarize currently available transgenic breast cancer mouse models that undergo spontaneous mammary tumorigenesis upon genetic manipulation, their varying characteristics, and their individual genetic manipulations that model aberrant signaling events observed in human breast cancers. |
| Databáze: | OpenAIRE |
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