High-density lipoprotein cholesterol levels are associated with coronary severity but not with outcomes in new-onset patients with stable coronary artery disease
| Autor: | Qian Dong, Na-Qiong Wu, Cheng-Gang Zhu, Hui-Hui Liu, Geng Liu, Ying Gao, Yuan-Lin Guo, Di Sun, Ping Qing, Xi Zhao, Jian-Jun Li, Yan Zhang, Sha Li |
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| Rok vydání: | 2017 |
| Předmět: |
Male
China medicine.medical_specialty medicine.medical_treatment Coronary Artery Disease Kaplan-Meier Estimate 030204 cardiovascular system & hematology Coronary Angiography Revascularization New onset Coronary artery disease 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine High-density lipoprotein Internal medicine medicine Humans Prospective Studies cardiovascular diseases 030212 general & internal medicine Myocardial infarction Stroke Aged Proportional Hazards Models Unstable angina Cholesterol business.industry Cholesterol HDL Cholesterol LDL Middle Aged medicine.disease Treatment Outcome chemistry Cardiology Female Cardiology and Cardiovascular Medicine business Follow-Up Studies |
| Zdroj: | Atherosclerosis. 263:104-111 |
| ISSN: | 0021-9150 |
| Popis: | The atheroprotective role of high-density lipoprotein cholesterol (HDL-C) levels in coronary artery disease (CAD) remains controversial. This study sought to reappraise the value of HDL-C in predicting the severity and outcomes of new-onset patients with stable CAD in Chinese populations.A total of 4205 new-onset patients with stable CAD who received coronary angiography were enrolled to analyze the relation of HDL-C to coronary severity and major adverse cardiovascular events (MACEs). Coronary severity was evaluated by Gensini scoring system. The MACEs included all-cause death, non-fatal myocardial infarction, stroke, unplanned revascularization and hospitalized unstable angina.Significantly, HDL-C levels were negatively associated with coronary severity (p 0.001). During an average of 27.32-month follow-up, 341 (8.12%) MACEs occurred. There was no significant difference of HDL-C levels between events group and non-events group. Furthermore, both Kaplan-Meier and Cox regression analyses found no relationship between HDL-C and cardiovascular outcomes (p 0.05).Plasma HDL-C levels appeared to be a predicator for coronary severity, but it is not associated with clinical outcomes in new-onset, Chinese patients with stable CAD. |
| Databáze: | OpenAIRE |
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