New in vitro kinetic model for evaluating bactericidal efficacy of antibiotics
| Autor: | Hiroshi Sakamoto, Minoru Nishida, T Hirose, Takeo Murakawa |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
medicine.drug_class
Klebsiella pneumoniae Antibiotics Cefazolin Microbial Sensitivity Tests Pharmacology Biology medicine.disease_cause Microbiology Minimum inhibitory concentration Pharmacokinetics Escherichia coli medicine Humans Pharmacology (medical) Bacteria biology.organism_classification In vitro Anti-Bacterial Agents Kinetics Infectious Diseases Injections Intravenous Research Article medicine.drug |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 18:377-381 |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.18.3.377 |
| Popis: | A new in vitro model was devised for evaluating the bactericidal activity of antibiotics under dynamic conditions. This model accurately reproduced the observed serum levels of antibiotics after intravenous dosing. The apparatus consists of two vessels which correspond to the central and peripheral compartments of a two-compartment open model. The volume of medium in each vessel and flow rates of media were determined from the pharmacokinetic parameters calculated from the observed serum levels selected for simulation. The bactericidal activity of cefazolin against strains of Escherichia coli and Klebsiella pneumoniae showing different minimal inhibitory concentrations was investigated with the apparatus simulating serum levels after intravenous injection, and the bactericidal activity was evaluated with respect to the relationship between the minimal inhibitory concentration and the serum levels. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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