Successful management of 3 dogs with colonic pythiosis using itraconzaole, terbinafine, and prednisone
| Autor: | Ann Della Maggiore, Patricia A. Pesavento, Bing Y. Zhu, Stanley L. Marks, Krystle L. Reagan, Amy M. Grooters |
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| Rok vydání: | 2019 |
| Předmět: |
Antifungal Agents
Gastrointestinal Diseases colitis Anti-Inflammatory Agents Case Report Case Reports 030204 cardiovascular system & hematology Pythium insidiosum Gastroenterology Oral and gastrointestinal 0403 veterinary science Pythiosis 0302 clinical medicine Prednisone Dog Diseases lcsh:Veterinary medicine Medical treatment biology 04 agricultural and veterinary sciences Itraconazole medicine.symptom medicine.drug medicine.medical_specialty Colon 040301 veterinary sciences Pythium Lesion 03 medical and health sciences Dogs Internal medicine oomycete medicine Animals Serologic Tests Veterinary Sciences Colitis Terbinafine General Veterinary business.industry medicine.disease biology.organism_classification lcsh:SF600-1100 SMALL ANIMAL Digestive Diseases business antifungal |
| Zdroj: | Journal of Veterinary Internal Medicine Journal of veterinary internal medicine, vol 33, iss 3 Journal of Veterinary Internal Medicine, Vol 33, Iss 3, Pp 1434-1439 (2019) |
| ISSN: | 1939-1676 0891-6640 |
| Popis: | Gastrointestinal (GI) pythiosis is a severe and often fatal disease in dogs that traditionally has been poorly responsive to medical treatment. Although aggressive surgical resection with wide margins is the most consistently effective treatment, lesion location and extent often preclude complete resection. Recently, it has been suggested that the addition of anti‐inflammatory doses of corticosteroids may improve outcome in dogs with nonresectable GI pythiosis. This report describes 3 dogs with colonic pythiosis in which complete resolution of clinical signs, regression of colonic masses, and progressive decreases in serological titers were observed after treatment with itraconazole, terbinafine, and corticosteroids. This treatment protocol represents a promising treatment for dogs with GI pythiosis in which surgical intervention is not feasible. |
| Databáze: | OpenAIRE |
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