SNP Variations in the 7q33 Region Containing DGKI are Associated with Dyslexia in the Finnish and German Populations
| Autor: | Johannes Schumacher, Jaana Nopola-Hemmi, Päivi Onkamo, Heidi Anthoni, Andreas Warnke, Heikki Lyytinen, Markus M. Nöthen, Myriam Peyrard-Janvid, Kristiina Tammimies, Juha Kere, Hans Matsson, Nina Neuhoff, Paavo H.T. Leppänen, G. Schulte-Körne, Marco Zucchelli |
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| Rok vydání: | 2011 |
| Předmět: |
Genetic Markers
Male Diacylglycerol Kinase Reading disability Candidate gene medicine.medical_specialty Genotype Polymorphism Single Nucleotide Cohort Studies Dyslexia DCDC2 Germany Molecular genetics Genetics medicine Humans SNP Longitudinal Studies Child Alleles Finland Genetic Association Studies Genetics (clinical) Ecology Evolution Behavior and Systematics Genetic association Haplotype Chromosome Mapping Genetic Variation medicine.disease Genetics Population Phenotype Haplotypes Female Psychology Chromosomes Human Pair 7 |
| Zdroj: | Behavior Genetics. 41:134-140 |
| ISSN: | 1573-3297 0001-8244 |
| DOI: | 10.1007/s10519-010-9431-4 |
| Popis: | Four genes, DYX1C1, ROBO1, DCDC2 and KIAA0319 have been studied both genetically and functionally as candidate genes for developmental dyslexia, a common learning disability in children. The identification of novel genes is crucial to better understand the molecular pathways affected in dyslectic individuals. Here, we report results from a fine-mapping approach involving linkage and association analysis in Finnish and German dyslexic cohorts. We restrict a candidate region to 0.3 Mb on chromosome 7q33. This region harbours the gene diacylglycerol kinase, iota (DGKI) which contains overlapping haplotypes associated with dyslexia in both Finnish and German sample sets. |
| Databáze: | OpenAIRE |
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