Koniamborine, the First Pyrano[3,2-b]indole Alkaloid and Other Secondary Metabolites from Boronella koniambiensis
Autor: | Raphaël Grougnet, Sofia Mitaku, Alexios-Leandros Skaltsounis, Marc Litaudon, Francois Tillequin, Prokopios Magiatis, Thierry Sévenet, Nikolas Fokialakis |
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Rok vydání: | 2005 |
Předmět: |
Pharmacology
Indole test Molecular Structure biology Indole alkaloid Stereochemistry Alkaloid Organic Chemistry Pharmaceutical Science Pharmacognosy biology.organism_classification Ring (chemistry) Heterocyclic Compounds 4 or More Rings Pyrone Indole Alkaloids Analytical Chemistry chemistry.chemical_compound New Caledonia Complementary and alternative medicine chemistry Drug Discovery Molecular Medicine Koniamborine Rutaceae Boronella |
Zdroj: | Journal of Natural Products. 68:1083-1086 |
ISSN: | 1520-6025 0163-3864 |
DOI: | 10.1021/np050013w |
Popis: | Two new alkaloids, (-)-cis-1,2-dihydroxy-1,2-dihydromedicosmine (3) and koniamborine (4), have been isolated from Boronella koniambiensis aerial parts. Their structures have been established from NMR and mass data. Koniamborine is a novel type of alkaloid, which derives from the pyrano[3,2-b]indole basic skeleton, described for the first time from nature. 6-Methoxy-1-methylisatin, also present in the plant material, can be considered biogenetically as a degradation product of the fused pyrone ring of 4. |
Databáze: | OpenAIRE |
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