No Association of IFNL4 Genotype With Opportunistic Infections and Cancers Among Men With Human Immunodeficiency Virus 1 Infection
| Autor: | Michelle Z Fang, Sarah S Jackson, Ruth M Pfeiffer, Eun-Young Kim, Sabrina Chen, Shehnaz K Hussain, Lisa P Jacobson, Jeremy Martinson, Ludmila Prokunina-Olsson, Chloe L Thio, Priya Duggal, Steven Wolinsky, Thomas R O’Brien |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Microbiology (medical)
Male Genotype HIV Infections Kaposi Opportunistic Infections Medical and Health Sciences Microbiology Cohort Studies Genetics Major Article Humans 2.2 Factors relating to the physical environment 2.1 Biological and endogenous factors Polymorphism Aetiology cytomegalovirus Cancer Interleukins interferon lambda Kaposi sarcoma Herpes Simplex Sarcoma Single Nucleotide interferon λ Biological Sciences herpes simplex virus Infectious Diseases Emerging Infectious Diseases Good Health and Well Being Cytomegalovirus Infections HIV-1 HIV/AIDS Digestive Diseases Infection |
| Zdroj: | Clin Infect Dis Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, vol 76, iss 3 |
| ISSN: | 3682-3481 |
| Popis: | Background IFNL4 genetic variants that are strongly associated with clearance of hepatitis C virus have been linked to risk of certain opportunistic infections (OIs) and cancers, including Kaposi sarcoma, cytomegalovirus infection, and herpes simplex virus infection. As the interferon (IFN) λ family plays a role in response to viral, bacterial, and fungal infections, IFNL4 genotype might affect risk for a wide range of OIs/cancers. Methods We examined associations between genotype for the functional IFNL4 rs368234815 polymorphism and incidence of 16 OIs/cancers among 2310 men with human immunodeficiency virus (2038 white; 272 black) enrolled in the Multicenter AIDS Cohort Study during 1984–1990. Our primary analyses used Cox proportional hazards models adjusted for self-reported racial ancestry to estimate hazard ratios with 95% confidence intervals, comparing participants with the genotypes that generate IFN-λ4 and those with the genotype that abrogates IFN-λ4. We censored follow-up at the introduction of highly effective antiretroviral therapies. Results We found no statistically significant association between IFNL4 genotype and the incidence of Kaposi sarcoma (hazard ratio, 0.92 [95% confidence interval, .76–1.11]), cytomegalovirus infection (0.94 [.71–1.24]), herpes simplex virus infection (1.37 [.68–2.93]), or any other OI/cancer. We observed consistent results using additive genetic models and after controlling for CD4 cell count through time-dependent adjustment or restriction to participants with a low CD4 cell count. Conclusions The absence of associations between IFNL4 genotype and these OIs/cancers provides evidence that this gene does not affect the risk of disease from opportunistic pathogens. |
| Databáze: | OpenAIRE |
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