Effects of ranibizumab on human corneal endothelial cells
| Autor: | Yi-Jung Ho, Chun-Chi Chiang, Jane-Ming Lin, Wen-Lu Chen, Chun-Ju Lin, Yi-Yu Tsai |
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| Jazyk: | angličtina |
| Předmět: |
medicine.medical_specialty
genetic structures business.industry intravitreal injection Macular degeneration medicine.disease Endothelial cell count eye diseases corneal endothelial cell Endothelial cell density Ophthalmology SPECULAR MICROSCOPY medicine Corneal endothelial cell In patient sense organs Ranibizumab Intravitreal ranibizumab ranibizumab business age-related macular degeneration medicine.drug |
| Zdroj: | Taiwan Journal of Ophthalmology. (3):120-122 |
| ISSN: | 2211-5056 |
| DOI: | 10.1016/j.tjo.2014.04.004 |
| Popis: | Purpose This study aims to evaluate corneal endothelial changes occurring over a 3-month period after intravitreal injections of ranibizumab in patients with wet age-related macular degeneration. Methods This is a prospective case series. A total of 29 patients (29 eyes) received a 0.5-mg intravitreal injection of ranibizumab. Specular microscopy, including measurement of central corneal thickness and endothelial cell count, was performed on each patient prior to and after completing three intravitreal injections. Results All patients received three intravitreal injections and were followed up for a mean of 3 months. There was no significant change in corneal thickness ( p = 0.32) or endothelial cell density ( p = 0.38) after ranibizumab injections. Conclusion Intravitreal ranibizumab injections (0.5 mg) have no harmful effects on corneal endothelial cells. |
| Databáze: | OpenAIRE |
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