Methicillin-resistant Staphylococcus aureus colonization and its association with infection among infants hospitalized in neonatal intensive care units
| Autor: | Yi-Hong Chou, Rey In Lien, Tzou Yien Lin, Yhu Chering Huang, Lin Hui Su |
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| Rok vydání: | 2006 |
| Předmět: |
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Bacterial Male Pediatrics medicine.medical_specialty Staphylococcus aureus Micrococcaceae Neonatal intensive care unit Taiwan Bacteremia Gestational Age Infant Premature Diseases Nose medicine.disease_cause Hospitals University Patient Isolation Intensive care Intensive Care Units Neonatal medicine Birth Weight Humans Colonization Ear External Skin Cross Infection biology Umbilicus business.industry Infant Newborn Sputum Infant Staphylococcal Infections medicine.disease biology.organism_classification Hospitals Pediatric Methicillin-resistant Staphylococcus aureus Bacterial Typing Techniques Low birth weight Premature birth Pediatrics Perinatology and Child Health Axilla Carrier State Female Methicillin Resistance medicine.symptom business Infant Premature |
| Zdroj: | Pediatrics. 118(2) |
| ISSN: | 1098-4275 |
| Popis: | OBJECTIVES. We conducted this study to assess the rate of methicillin-resistant Staphylococcus aureus colonization and its association with infection among infants hospitalized in methicillin-resistant S aureus–endemic NICUs. METHODS. Between March 2003 and February 2004, surveillance culture specimens from the nares, postauricular areas, axillae, and umbilicus of infants admitted to the NICUs at a children’s hospital in Taiwan were obtained weekly for the detection of methicillin-resistant S aureus. All colonized and clinical isolates from each study infant with methicillin-resistant S aureus infection were genotyped with pulsed-field gel electrophoresis, with Sma1 digestion, and compared. RESULTS. A total of 783 infants were included in this study. Methicillin-resistant S aureus colonization was detected for 323 infants during their NICU stays, with detection with the first 2 samples for 89%. Nares and umbilicus were the 2 most common sites of initial colonization. Methicillin-resistant S aureus colonization was associated significantly with premature birth (≤28 weeks) and low birth weight (≤1500 g), and infants with colonization had a significantly higher rate of methicillin-resistant S aureus infection, compared with those without colonization (26% vs 2%). Methicillin-resistant S aureus colonization was noted for 84 of 92 infants with methicillin-resistant S aureus infections. Of the 68 episodes with previous colonization and isolates available for genotyping analysis, colonized and clinical isolates were indistinguishable in 63 episodes, highly related in 2 episodes, and distinct in 3 episodes. CONCLUSIONS. More than 40% of the hospitalized infants were colonized with methicillin-resistant S aureus during their stay in methicillin-resistant S aureus–endemic NICUs; this was associated significantly with methicillin-resistant S aureus infection. Most infants with methicillin-resistant S aureus infections had previous colonization with an indistinguishable strain. |
| Databáze: | OpenAIRE |
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