Octopaminergic neurons have multiple targets in Drosophila larval mushroom body calyx and can modulate behavioral odor discrimination
| Autor: | Cahir J. O'Kane, Tom Bland, Marcella Montagnese, J.Y. Hilary Wong, Bo Angela Wan, Alex D McLachlan, Shuo Wei Zhang, Liria M. Masuda-Nakagawa |
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| Přispěvatelé: | Masuda-Nakagawa, Liria M [0000-0002-2504-3379], Apollo - University of Cambridge Repository |
| Rok vydání: | 2021 |
| Předmět: |
Cognitive Neuroscience
Sensory system Context (language use) Optogenetics Biology Calyx 03 medical and health sciences Cellular and Molecular Neuroscience Discrimination Psychological 0302 clinical medicine Animals Learning Octopamine Mushroom Bodies Neurons Behavior Animal Research Olfactory Perception Neuropsychology and Physiological Psychology nervous system Odor Larva Mushroom bodies Drosophila Octopamine (neurotransmitter) Olfactory Learning Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Learn Mem |
| ISSN: | 1549-5485 |
| Popis: | Discrimination of sensory signals is essential for an organism to form and retrieve memories of relevance in a given behavioral context. Sensory representations are modified dynamically by changes in behavioral state, facilitating context-dependent selection of behavior, through signals carried by noradrenergic input in mammals, or octopamine (OA) in insects. To understand the circuit mechanisms of this signaling, we characterized the function of two OA neurons, sVUM1 neurons, that originate in the subesophageal zone (SEZ) and target the input region of the memory center, the mushroom body (MB) calyx, in larval Drosophila. We found that sVUM1 neurons target multiple neurons, including olfactory projection neurons (PNs), the inhibitory neuron APL, and a pair of extrinsic output neurons, but relatively few mushroom body intrinsic neurons, Kenyon cells. PN terminals carried the OA receptor Oamb, a Drosophila α1-adrenergic receptor ortholog. Using an odor discrimination learning paradigm, we showed that optogenetic activation of OA neurons compromised discrimination of similar odors but not learning ability. Our results suggest that sVUM1 neurons modify odor representations via multiple extrinsic inputs at the sensory input area to the MB olfactory learning circuit. |
| Databáze: | OpenAIRE |
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