Lateralization of CA1 assemblies in the absence of CA3 input
| Autor: | Steven J. Middleton, Thomas J. McHugh, Takafumi Inoue, Hefei Guan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
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Science Population General Physics and Astronomy Hippocampal formation Neurotransmission Biology Hippocampus Neural circuits Synaptic Transmission General Biochemistry Genetics and Molecular Biology Lateralization of brain function Article Functional Laterality Mice Tetanus Toxin Neural Pathways Animals Wakefulness education CA1 Region Hippocampal education.field_of_study Multidisciplinary musculoskeletal neural and ocular physiology Excitatory Postsynaptic Potentials General Chemistry CA3 Region Hippocampal nervous system Place Cells Neuroscience |
| Zdroj: | Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021) Nature Communications |
| ISSN: | 2041-1723 |
| Popis: | In the hippocampal circuit CA3 input plays a critical role in the organization of CA1 population activity, both during learning and sleep. While integrated spatial representations have been observed across the two hemispheres of CA1, these regions lack direct connectivity and thus the circuitry responsible remains largely unexplored. Here we investigate the role of CA3 in organizing bilateral CA1 activity by blocking synaptic transmission at CA3 terminals through the inducible transgenic expression of tetanus toxin. Although the properties of single place cells in CA1 were comparable bilaterally, we find a decrease of ripple synchronization between left and right CA1 after silencing CA3. Further, during both exploration and rest, CA1 neuronal ensemble activity is less coordinated across hemispheres. This included degradation of the replay of previously explored spatial paths in CA1 during rest, consistent with the idea that CA3 bilateral projections integrate activity between left and right hemispheres and orchestrate bilateral hippocampal coding. Bilaterally projecting CA3 inputs may be crucial for integrating the left and right CA1 during memory but this has not been directly examined. Here, the authors show that projections from bilateral CA3 play a key role in the cross-hemispheric coordination of CA1 spatial coding. |
| Databáze: | OpenAIRE |
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