A comparison of nephrotoxicity between patients with a solitary-functioning kidney and those with bilateral-functioning kidneys in cisplatin-based chemotherapy for advanced urothelial carcinoma: a Japanese retrospective multi-institutional study

Autor:	Hiroyuki Nishiyama, Yusuke Shiraishi, Takeshi Nomoto, Hironobu Wakeda, Koji Mitsuzuka, Eiji Kikuchi, Jun Miyazaki, Yoshiyuki Matsui, Daishi Ichioka, Shintaro Narita, Takamitsu Inoue, Susumu Kageyama, Keiko Fujie, Tomonori Habuchi, Hidefumi Kinoshita, Mikio Sugimoto
Rok vydání:	2018
Předmět:	Male Urologic Neoplasms Cancer Research medicine.medical_specialty medicine.medical_treatment Urinary system 030232 urology & nephrology Urology Renal function Antineoplastic Agents Kidney Nephroureterectomy lcsh:RC254-282 Nephrotoxicity 03 medical and health sciences 0302 clinical medicine Solitary kidney Genetics medicine Humans Neoplasm Metastasis Hydronephrosis Aged Retrospective Studies Upper urinary tract Cisplatin Chemotherapy business.industry Prognosis lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Female Urothelial carcinoma business Follow-Up Studies Glomerular Filtration Rate Research Article medicine.drug
Zdroj:	BMC Cancer, Vol 18, Iss 1, Pp 1-11 (2018) BMC Cancer
ISSN:	1471-2407
DOI:	10.1186/s12885-018-4186-z
Popis:	Background To compare the prevalence of nephrotoxicity between patients with a solitary-functioning kidney versus those with bilateral-functioning kidneys during the administration of cisplatin-based chemotherapy for advanced urothelial carcinoma. Methods We retrospectively analyzed 244 advanced urothelial carcinoma patients treated with cisplatin-based chemotherapy between 2004 and 2010 at 17 institutes in Japan. The 24 h creatinine clearance, Cockcroft–Gault formula, and estimated glomerular filtration rate equation (eGFR), were compared before all chemotherapies. The urinary tract function status was determined based on the data of nephroureterectomy, hydronephrosis, and relief of upper urinary tract obstruction. A total of 244 patients were divided into four groups according to their urinary tract functioning status and eGFR results, including bilateral-functioning kidneys with pretreatment eGFR ≥60 mL/min/1.73 m2 group (n = 83, 34.0%); a solitary-functioning kidney with pretreatment eGFR ≥60 mL/min/1.73 m2 group (n = 36, 14.8%); bilateral-functioning kidneys with pretreatment eGFR 10% and 30% from baseline in the post-third-course of chemotherapy was significantly higher in patients with bilateral-functioning kidneys than in those with a solitary-functioning kidney, among patients with pretreatment eGFR 20% from baseline were significantly higher in patients with bilateral-functioning kidneys than those with a solitary-functioning kidney among patients with pretreatment eGFR
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aba9ed979a5d7cf3c5c58bb9f6207449 https://doi.org/10.1186/s12885-018-4186-z Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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