Continuous Regional Arterial Infusion of Protease Inhibitors Has No Efficacy in the Treatment of Severe Acute Pancreatitis
| Autor: | Masayasu Horibe, Toshihiko Mayumi, Kunihiro Shirai, Dai Miyazaki, Tetsu Ozaki, Wataru Shinomiya, Mitsuhito Sasaki, Morihisa Hirota, Yoshiyuki Yamagishi, Takashi Moriya, Daisuke Sugiyama, Taku Oshima, Takuya Oda, Tsukasa Ikeura, Nobutaka Chiba, Katsuya Kitamura, Hideto Yasuda, Takahiro Yamashita, Toshitaka Koinuma, Takashi Goto, Hirotaka Sawano, Tomonori Yamamoto, Eisuke Iwasaki, Tsuyoshi Hamada, Masamitsu Sanui, Kaoru Hirose, Takanori Kanai |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment protease inhibitors Acute necrotizing Severity of Illness Index acute necrotizing pancreatitis 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine Severity of illness Internal Medicine medicine Humans Infusions Intra-Arterial In patient Aged Retrospective Studies continuous regional arterial infusion Protease treatment Hepatology Pancreatitis Acute Necrotizing business.industry Retrospective cohort study Original Articles Middle Aged medicine.disease Surgery Logistic Models Treatment Outcome Pancreatitis 030220 oncology & carcinogenesis Acute Disease Multivariate Analysis Acute pancreatitis Female 030211 gastroenterology & hepatology business severe acute pancreatitis Cohort study |
| Zdroj: | Pancreas |
| ISSN: | 0885-3177 |
| DOI: | 10.1097/mpa.0000000000000775 |
| Popis: | Objective The aim of this study is to assess the effectiveness of continuous regional arterial infusion (CRAI) of protease inhibitors in patients with severe acute pancreatitis (SAP) including acute necrotizing pancreatitis. Methods This retrospective study was conducted among 44 institutions in Japan from 2009 to 2013. Patients 18 years or older diagnosed with SAP according to the criteria of the Japanese Ministry of Health, Labour and Welfare study group (2008) were consecutively enrolled. We evaluated the association between CRAI of protease inhibitors and mortality, incidence of infection, and the need for surgical intervention using multivariable logistic regression analysis. Results Of 1159 patients admitted, 1097 patients with all required data were included for analysis. Three hundred and seventy-four (34.1%) patients underwent CRAI of protease inhibitors and 723 (65.9%) did not. In multivariable analysis, CRAI of protease inhibitors was not associated with a reduction in mortality, infection rate, or need for surgical intervention (odds ratio [OR] 0.79, 95% confidence interval [CI] 0.47–1.32, P = 0.36; OR 0.97, 95% CI 0.61–1.54, P = 0.89; OR 0.76, 95% CI 0.50–1.15, P = 0.19; respectively). Conclusions Continuous regional arterial infusion of protease inhibitors was not efficacious in the treatment of patients with SAP. |
| Databáze: | OpenAIRE |
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