Spontaneous lesions of nasal cavity in aging F344 rats and BDF1 mice
| Autor: | K. Nagano, H. Senoh, Y. Sakura, S. Aiso, T. Takeuchi, T. Katagiri |
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| Rok vydání: | 1997 |
| Předmět: |
Male
Nasal cavity Aging Pathology medicine.medical_specialty Biology Toxicology Epithelium Pathology and Forensic Medicine Lesion Mice Olfactory Mucosa Species Specificity Metaplasia Eosinophilia Nose Diseases Eosinophilic medicine Animals Respiratory system Nose Foreign-Body Reaction Thrombosis Cell Biology General Medicine Rats Inbred F344 Rats Mice Inbred C57BL medicine.anatomical_structure Mice Inbred DBA Respiratory epithelium Calcium Female Nasal Cavity medicine.symptom Olfactory epithelium |
| Zdroj: | Experimental and Toxicologic Pathology. 49:97-104 |
| ISSN: | 0940-2993 |
| DOI: | 10.1016/s0940-2993(97)80077-2 |
| Popis: | The outline of spontaneous lesions of the nasal cavity that were commonly observed in F344 rats and BDF1 mice used as untreated control groups in ten 2-year carcinogenicity studies were presented. In rats, the common spontaneous lesions were eosinophilic change of the respiratory epithelium and the olfactory epithelium, respiratory metaplasia of glands and the olfactory epithelium, foreign body inflammation, deposit of calcium, and thrombus. In mice, the common spontaneous lesions were eosinophilic change of the respiratory epithelium and olfactory epithelium, and respiratory metaplasia of glands and the olfactory epithelium. Some of these lesions revealed either species or sex-related differences of incidence. |
| Databáze: | OpenAIRE |
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