High Prevalence of Osteopathy in Chronic Pancreatitis: A Cross-sectional Analysis From the PROCEED Study
Autor: | Phil A. Hart, Stephen J. Pandol, Dhiraj Yadav, William E. Fisher, Santhi Swaroop Vege, Evan L. Fogel, Chris E. Forsmark, Darwin L. Conwell, Mark Topazian, Jose Serrano, David Bradley, Stephen K Van Den Eden, Walter G. Park, Savi Appana, Liang Li |
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Rok vydání: | 2022 |
Předmět: |
Male
medicine.medical_specialty Cross-sectional study Population Bone Density Risk Factors Pancreatitis Chronic Internal medicine Prevalence medicine Humans Prospective Studies Prospective cohort study education Dual-energy X-ray absorptiometry Retrospective Studies education.field_of_study Hepatology medicine.diagnostic_test business.industry Gastroenterology Odds ratio medicine.disease Osteopenia Bone Diseases Metabolic Cross-Sectional Studies Osteopathy Osteoporosis Female Underweight medicine.symptom business |
Zdroj: | Clinical Gastroenterology and Hepatology. 20:2005-2013 |
ISSN: | 1542-3565 |
Popis: | Background & Aims Chronic pancreatitis (CP) is associated with osteopathy (osteoporosis or osteopenia). However, existing literature is mostly limited to retrospective or administrative studies that have not clearly defined the prevalence and risk factors. Our aim was to identify patient- and disease-related associations with osteopathy in a prospective cohort study of CP. Methods We studied 282 subjects with definitive CP enrolled in the PROCEED study who had a baseline dual-energy X-ray absorptiometry (DXA) scan. Osteopenia and osteoporosis were defined using the lowest T-scores. Clinical data were collected using standardized case report forms. Comparisons were performed with a multivariate logistic regression model with forward selection to identify risk factors for osteopathy. Results The majority of subjects had osteopathy on DXA scan (56.0%; 17.0% osteoporosis; 39.0% osteopenia). Subjects with osteopathy had a higher prevalence of traumatic (40.0% vs 26.4%; P = .02) and spontaneous fractures (3.9% vs 0; P = .04). On multivariate analysis, older age (odds ratio [OR], 1.29 per 5 years; 95% confidence interval [CI], 1.15–1.45), female sex (OR, 3.08; 95% CI, 1.75–5.43), white race (OR, 2.68; 95% CI, 1.20–6.01), and underweight body mass index category (OR, 7.40; 95% CI, 1.56–34.99) were associated with higher probability of osteopathy. There were no significant associations between osteopathy and other patient and disease-related features of CP. Conclusion In the largest study of patients with CP who underwent DXA screening, the majority had osteopathy. There are overlapping risk factors with osteopathy in the general population, but the high prevalence in men and younger women supports the need for future investigations into the mechanisms of bone loss in CP. ClinicalTrials.gov number, NCT03099850. |
Databáze: | OpenAIRE |
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