Effect of Interleukin-10 on Localization of AMPA Receptors in Synapses during Long-Term Posttetanic Potentiation in Cultured Hippocampal Slices
| Autor: | S. G. Levin, I. B. Mikheeva, V. I. Arkhipov, A. E. Malkov, L. L. Pavlik |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male Long-Term Potentiation AMPA receptor Hippocampal formation In Vitro Techniques Hippocampus General Biochemistry Genetics and Molecular Biology Synapse 03 medical and health sciences 0302 clinical medicine Animals Receptors AMPA Rats Wistar Receptor Chemistry musculoskeletal neural and ocular physiology Long-term potentiation General Medicine Immunohistochemistry Cell biology Interleukin-10 Rats Interleukin 10 030104 developmental biology nervous system Synaptic plasticity Postsynaptic density 030217 neurology & neurosurgery |
| Zdroj: | Bulletin of experimental biology and medicine. 167(1) |
| ISSN: | 1573-8221 |
| Popis: | The effect of the anti-inflammatory cytokine IL-10 on the ultrastructural distribution of AMPA receptor GluR1 subunit in CA1 field of cultured hippocampal slices was studied by using immunohistochemical technique. It was found that long-term posttetanic potentiation increased the content of GluR1 in the postsynaptic density of the axo-spinous synapse. Addition of IL-10 in concentrations of 1 and 10 ng/ml to the medium facilitated long-term posttetanic potentiation thereby changing the distribution of GluR1 in the spine: the number of receptors increased in the cytoplasm and decreased in the postsynaptic density. It is assumed that activation of neuronal IL-10 receptors affects the distribution of AMPA receptors in axo-spinous synapses of hippocampal field CA1 through interplay of intracellular signaling pathways, thereby participating in the mechanisms of synaptic plasticity under normal conditions. |
| Databáze: | OpenAIRE |
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