A tiered approach to prioritizing registered pesticides for potential cancer hazard evaluations: implications for decision making
Autor: | Ruth M. Lunn, Pamela J. Schwingl, Suril S. Mehta |
---|---|
Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Epidemiology
Health Toxicology and Mutagenesis Decision Making 010501 environmental sciences Hazard analysis Evidence mapping 01 natural sciences Risk Assessment 03 medical and health sciences lcsh:RC963-969 0302 clinical medicine Environmental health Neoplasms Medicine Humans 030212 general & internal medicine Pesticides 0105 earth and related environmental sciences Cancer business.industry Research lcsh:Public aspects of medicine Public Health Environmental and Occupational Health lcsh:RA1-1270 Pesticide Tiered approach medicine.disease Hazard United States Hazard identification Agriculture Carcinogens lcsh:Industrial medicine. Industrial hygiene business Human cancer Scoping |
Zdroj: | Environmental Health, Vol 20, Iss 1, Pp 1-14 (2021) Environmental Health |
Popis: | Background Over 800 pesticides are registered for use in the United States. Human studies indicate concern that some pesticides currently in use in large quantities may also pose a carcinogenic hazard. Our objective is to identify candidates for future hazard evaluations among pesticides used in high volumes in the United States and also classified as potential carcinogens by U.S. Environmental Protection Agency (USEPA). We also identify data gaps where further research is needed. Methods We used a systematic, two-tiered review approach to prioritize pesticides. First, we identified currently registered pesticides classified by USEPA as “possible”, “suggestive”, or “likely” human carcinogens. Among these, we selected pesticides USEPA has listed as commonly used by volume in at least one sector (agriculture, home and garden, or industry, commercial, and/or government), and those without a published hazard evaluation in the past 5 years. Second, we searched primary literature databases for peer-reviewed human cancer studies reporting pesticide-specific data published since the last USEPA carcinogenicity evaluation for each pesticide, and created evidence maps of the number of studies meeting our criteria for each identified pesticide. No evaluation of study results or risk-of-bias assessments were conducted. Results We identified 18 pesticides meeting our selection criteria, 16 pesticides had information from human cancer studies published after their initial carcinogenicity review. Of these, eight pesticides had at least three studies for one or more cancer sites: carbaryl, dichloropropene, dimethoate, mancozeb, metolachlor, pendimethalin, permethrin, and trifluralin. A major limitation in the literature revealed a shortage of studies reporting risk estimates for individual pesticides, rather pesticides were grouped by chemical class. Conclusions Our scoping report provides a map of the existing literature on real-world exposures and human cancer that has accumulated on pesticides classified as potential carcinogens by USEPA and used in high volumes. We also illustrate that several pesticides which are “data-rich” may warrant updated authoritative hazard evaluations. Our two-tiered approach and utilization of evidence mapping can be used to inform future decision-making to update cancer hazard evaluations. |
Databáze: | OpenAIRE |
Externí odkaz: | |
Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |