Metabolic Alteration in Plasma and Biopsies From Patients With IBD
| Autor: | Martina Spada, Antonio Murgia, Pierluigi Caboni, Aldo Manzin, Maria Laura Santoru, Sonia Liggi, Paolo Usai, Federica Murgia, Luigi Atzori, Cristina Piras, Maria Antonia Lai, Vera Piera Leoni |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Biopsy Ileum Gastroenterology Inflammatory bowel disease Pathogenesis Plasma 03 medical and health sciences 0302 clinical medicine Crohn Disease Internal medicine medicine Humans Immunology and Allergy Irritable bowel syndrome Gastrointestinal tract Crohn's disease medicine.diagnostic_test business.industry medicine.disease Ulcerative colitis 030104 developmental biology medicine.anatomical_structure Metabolome Colitis Ulcerative 030211 gastroenterology & hepatology business |
| Zdroj: | Inflammatory Bowel Diseases. 27:1335-1345 |
| ISSN: | 1536-4844 1078-0998 |
| Popis: | Background Inflammatory bowel diseases (IBD) are chronic inflammatory disorders of the gastrointestinal tract, with periods of latency alternating with phases of exacerbation, and include 2 forms: Crohn disease (CD) and ulcerative colitis (UC). Although the etiology of IBD is still unclear, the identification and understanding of pathophysiological mechanisms underlying IBD could reveal newly targeted intestinal alterations and determine therapeutic approaches. Methods In this study, by using gas chromatography-mass spectrometry, we characterized plasma and biopsies from the metabolomics profiles of patients with IBD compared with those of a control group. Results The results showed a different metabolomics profile between patients with CD (n = 50) and patients with UC (n = 82) compared with the control group (n = 51). Multivariate statistical analysis of the identified metabolites in CD and UC showed changes in energetic metabolism, and lactic acid and ornithine in particular were altered in both plasma and colon biopsies. Moreover, metabolic changes were evidenced between the normal ileum and colon tissues. These differences disappeared when we compared the inflamed ileum and colon tissues, suggesting a common metabolism. Conclusions This study showed how the metabolomics profile could be a potential tool to identify intestinal alterations associated with IBD and may have application in precision medicine and for better defining the pathogenesis of the disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|