Treatment of Hypertension Because of Immunosuppressive Therapy After Solid Organ Transplantation—Pharmacological Approach
| Autor: | Joanna Banach, Daniel Rogowicz, Grzegorz Grześk, Łukasz Wołowiec, Sławomir Sielski, Wojciech Gilewski |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Calcineurin Inhibitors 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Immune system medicine Animals Humans Intensive care medicine Antihypertensive Agents Immunosuppression Therapy Pharmacology business.industry Organ Transplantation Calcineurin Transplantation 030104 developmental biology Mechanism of action Hypertension medicine.symptom Cardiology and Cardiovascular Medicine business Solid organ transplantation Immunosuppressive Agents |
| Zdroj: | Journal of Cardiovascular Pharmacology. 77:735-744 |
| ISSN: | 0160-2446 |
| DOI: | 10.1097/fjc.0000000000001009 |
| Popis: | Solid organs transplantation procedures have been performed for more than half a century. Growing knowledge of immune response and development of new immunosuppressive regimens guarantee more and more successful outcomes. However, many of the applied drugs lead to cardiovascular complications, the most frequent of which is hypertension. This article describes epidemiology, pathogenetic mechanisms, and treatment of hypertension induced by immunosuppressive medication. The main impact is focused on drugs belonging to the following groups: calcineurin inhibitors, the inhibitors of the mammalian target of rapamycin, and glucocorticosteroids. We analyze the mechanism of action of the main hypertensive drugs and their influence on the reversing hypertonic action of the immunosuppressive agents. In the absence of current guidelines addressing this problem, this article is an attempt to fill the gap, helping clinicians to choose proper medication. |
| Databáze: | OpenAIRE |
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