Expression and clinical significance of FXYD3 in endometrial cancer
Autor: | Jing Ge, Yali Meng, Jing Liu, Xiao-Feng Sun, Yifei Li, Xia Zhang, Lin Li, Hong-Zhen Zhang, Shuwen Xu, Guiying Fang |
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Jazyk: | angličtina |
Rok vydání: | 2014 |
Předmět: |
Cancer Research
Pathology medicine.medical_specialty Oncogene business.industry Endometrial cancer Cancer Articles medicine.disease Atypical hyperplasia Endometrial hyperplasia Oncology immunohistochemistry medicine Carcinoma endometrial neoplasm business FXYD3 Atypical Endometrial Hyperplasia endometrial hyperplasia Endometrial Neoplasm |
Zdroj: | Oncology Letters |
ISSN: | 1792-1082 1792-1074 |
Popis: | FXYD3 expression is upregulated in numerous cancer cell types. The present study compared the FXDY3 expression in normal endometrium, premalignant lesion and endometrial cancer tissue samples, and investigated the correlation between FXDY3 expression and clinicopathological features. FXYD3 expression was analyzed by streptavidin-peroxidase immunohistochemistry in 21 normal endometrial tissue samples, 18 atypical endometrial hyperplasia samples and 50 tissues obtained from patients diagnosed with endometrial cancer. The percentage of FXYD3-positive cell expression in the normal endometrium, atypical hyperplasia and endometrial cancer tissues samples was 0, 22, and 26%, respectively. The differences between the atypical hyperplasia and endometrial cancer groups were statistically significant when compared with the normal group (P=0.007 and P=0.037, respectively). There was no significant difference between the atypical hyperplasia and endometrial cancer groups. The percentage of FXYD3-positive cells correlated with the fertility frequency (P |
Databáze: | OpenAIRE |
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