Short- and Branched-Chain Fatty Acids as Fecal Markers for Microbiota Activity in Vegans and Omnivores
Autor: | Cornelia Weikert, Stefan Dietrich, Klaus Abraham, Annett Braune, Iris Trefflich |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
Adult Male intestinal microbiota Diet Vegan fecal pH short-chain fatty acids Faecalibacterium prausnitzii digestive system Article 03 medical and health sciences Feces 0302 clinical medicine Clostridium Ammonia Humans TX341-641 Eubacterium Food science Vegans Nutrition and Dietetics biology Bacteria Nutrition. Foods and food supply Chemistry Ruminococcus Fatty Acids digestive oral and skin physiology Vegan Diet Biodiversity Nutrients vegan diet Hydrogen-Ion Concentration Middle Aged biology.organism_classification Body Fluids Diet Gastrointestinal Microbiome 030104 developmental biology Cross-Sectional Studies branched-chain fatty acids 030211 gastroenterology & hepatology Female Omnivore Bacteroides Biomarkers Food Science |
Zdroj: | Nutrients Volume 13 Issue 6 Nutrients, Vol 13, Iss 1808, p 1808 (2021) |
ISSN: | 2072-6643 |
DOI: | 10.3390/nu13061808 |
Popis: | A vegan diet could impact microbiota composition and bacterial metabolites like short-chain (SCFA) and branched-chain fatty acids (BCFA). The aim of this study was to compare the concentrations of SCFA, BCFA, ammonia, and fecal pH between vegans and omnivores. In this cross-sectional study (vegans n = 36 omnivores n = 36), microbiota composition, fecal SCFA, BCFA, and ammonia concentrations and pH were analyzed in complete stool samples. A random forest regression (RFR) was used to identify bacteria predicting SCFA/BCFA concentrations in vegans and omnivores. No significant differences in SCFA and BCFA concentrations were observed between vegans and omnivores. Fecal pH (p = 0.005) and ammonia concentration (p = 0.01) were significantly lower in vegans than in omnivores, while fiber intake was higher (p < 0.0001). Shannon diversity was higher in omnivores compared to vegans on species level (p = 0.04) only. In vegans, a cluster of Faecalibacterium prausnitzii, Prevotella copri, Dialister spp., and Eubacterium spp. was predictive for SCFA and BCFA concentrations. In omnivores, Bacteroides spp., Clostridium spp., Ruminococcus spp., and Prevotella copri were predictive. Though SCFA and BCFA did not differ between vegans and omnivores, the results of the RFR suggest that bacterial functionality may be adapted to varying nutrient availability in these diets. |
Databáze: | OpenAIRE |
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